In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- in situ cytokine detection: interleukin 18
研究概览
简要总结
The investigators aim at exploring the differential/topographical in-situ expression of cytokines in the central nervous system (CNS) of patients who died with amyotrophic lateral sclerosis (ALS), using archived histopathology slides and residual paraffin blocks from autopsied cases. Previous studies from the investigators and other groups showed that inflammatory cytokines are implicated in several neurological affections, particularly neurodegenerative conditions. However, in-situ cytokine expression has never been studied so far in ALS. The investigators wanted to see if these neuro-mediators are involved in the neuromolecular chain/cascade underlying ALS.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who died with amyotrophic lateral sclerosis, having been autopsied.
排除标准
- 未提供
结局指标
主要结局
in situ cytokine detection: interleukin 18
时间窗: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005
IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection: interleukin 1
时间窗: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005
IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection: interleukin 6
时间窗: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005
IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection:TNF-a
时间窗: retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005
IHC detection on histopathology sections of paraffin embedded brain tissue.
次要结局
未报告次要终点
研究者
Carine DE PREZ
Head of clinic
Brugmann University Hospital