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临床试验/NCT06359977
NCT06359977尚未招募不适用

The Effect of Quantitative Electroencephalography Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure in Neurocritical Patients

Qingdao University0 个研究点目标入组 50 人开始时间: 2024年4月15日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
50
主要终点
Respiratory muscles thickening fraction (%)

研究概览

简要总结

Neurocritical patients often face the need for removal of endotracheal tubes. However, despite following the extubation criteria for general critical ill patients, neurocritical patients still exhibit a higher rate of weaning failure, significantly higher than that of general critical ill patients. The extubation criteria for general critical patients emphasize the assessment of lung conditions. However, neurological critical patients often have less severe lung damage, but factors such as consciousness level and coughing ability may significantly influence extubation. Quantitative EEG serves as an objective tool to reflect consciousness level status, while bedside ultrasound can assess respiratory muscle function. Additionally, sputum volume may reflect the condition of lung condition. Therefore, we believe that combination of these three indicators can better predict the success of extubation for neurocritical patients.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Neurocritical patients with endotracheal intubation;
  • Successful spontaneous Breathing Trial;
  • The patients meet extubation criteria evaluated by clinical physician

排除标准

  • Patients whose families have opted for cessation of treatment.

结局指标

主要结局

Respiratory muscles thickening fraction (%)

时间窗: 2 hours before extubation

Muscle thickening fraction was evaluated by ultrasound. It equals (end-inspiratory thickness - end-expiratory thickness)/end-expiratory thickness × 100%.

Quantitative EEG indicators

时间窗: 2 hours before extubation

These indicators including amplitude EEG and the proportion of α,β,δ,θ wave

Respiratory muscles thickness in centimeter

时间窗: 2 hours before extubation

Muscle thickness was evaluated by ultrasound.

Sputum volume in milliliter

时间窗: 24 hours before extubation

The amount of sputum

次要结局

未报告次要终点

研究者

发起方
Qingdao University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Bo Yao,phD

The department of critical care medicine, Affiliated hospital of Qingdao university

Qingdao University

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