The Effect of Quantitative Electroencephalography Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure in Neurocritical Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 主要终点
- Respiratory muscles thickening fraction (%)
研究概览
简要总结
Neurocritical patients often face the need for removal of endotracheal tubes. However, despite following the extubation criteria for general critical ill patients, neurocritical patients still exhibit a higher rate of weaning failure, significantly higher than that of general critical ill patients. The extubation criteria for general critical patients emphasize the assessment of lung conditions. However, neurological critical patients often have less severe lung damage, but factors such as consciousness level and coughing ability may significantly influence extubation. Quantitative EEG serves as an objective tool to reflect consciousness level status, while bedside ultrasound can assess respiratory muscle function. Additionally, sputum volume may reflect the condition of lung condition. Therefore, we believe that combination of these three indicators can better predict the success of extubation for neurocritical patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Neurocritical patients with endotracheal intubation;
- •Successful spontaneous Breathing Trial;
- •The patients meet extubation criteria evaluated by clinical physician
排除标准
- •Patients whose families have opted for cessation of treatment.
结局指标
主要结局
Respiratory muscles thickening fraction (%)
时间窗: 2 hours before extubation
Muscle thickening fraction was evaluated by ultrasound. It equals (end-inspiratory thickness - end-expiratory thickness)/end-expiratory thickness × 100%.
Quantitative EEG indicators
时间窗: 2 hours before extubation
These indicators including amplitude EEG and the proportion of α,β,δ,θ wave
Respiratory muscles thickness in centimeter
时间窗: 2 hours before extubation
Muscle thickness was evaluated by ultrasound.
Sputum volume in milliliter
时间窗: 24 hours before extubation
The amount of sputum
次要结局
未报告次要终点
研究者
Bo Yao,phD
The department of critical care medicine, Affiliated hospital of Qingdao university
Qingdao University
