Predictive Value of Endometrial Cytokines in Endometrial Implantation in Cases of Intracytoplasmic Sperm Injection
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Measurement of Tumor Necrosis Factor (TNF)-a
研究概览
简要总结
For all women immediately after ovum retrieval from 80 women undergoing IVF, intra uterine salin flushing will be analyzed using a multiplex immunoassay for soluble regulators of implantation, namely Interleukin (IL)-1b, Tumor Necrosis Factor (TNF)-a,. In order to detect implantation predictors.
详细描述
This is a prospective cohort study, performed on 80 women attending Obstetrics and Gynecology Department of Benha University Hospital for invitro fertilization/intracytoplasmic sperm injection treatment and private IVF centers. None undergoes more than one prior unsuccessful embryo transfer.
Method of randomization:
Simple random sample, which is a subset of individuals (a sample) chosen from a larger set (a population). Each individual is chosen randomly and entirely by chance, so each individual has the sample probability of being chosen at any stage during the sampling process, and each subset of k individuals has the same probability of being chosen for the sample as any other subset of k individuals (Yates et al., 2008).
Methods:
The patients will be subjected to the following:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age younger than 37 years.
- •Having a regular and proven ovulatory menstrual cycles with a length of 26-35 days.
- •Body mass index less than 35 kg/m
- •Serum follicle stimulating hormone and estradiol were within normal ranges.
排除标准
- •Gross uterine pathology.
结局指标
主要结局
Measurement of Tumor Necrosis Factor (TNF)-a
时间窗: 2 days
Measurement of Interleukin (IL)-1b
时间窗: 2 days
次要结局
- serum pregnancy test(14 days)
研究者
khalid mohammed salama
director clinical research
Benha University