Prospective Clinical Trial on Validation and Comparison of the Diagnostic and Prognostic Value of Appendicitis Inflammatory Response Score and Adult Appendicitis Score
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 174
- 试验地点
- 1
- 主要终点
- Exclude acute appendicitis
研究概览
简要总结
Acute appendicitis is one of the most frequent reasons of emergency laparotomy in adults. Symptoms of acute appendicitis overlap with other clinical conditions and might present as a challenge, especially in the early phases. Despite the advances and widespread use of imaging modalities, still negative laparotomies are performed with the initial diagnosis of acute appendicitis. Several scoring systems are developed by using various clinical and laboratory parameters in order to improve the diagnostic accuracy and prevent unnecessary laparotomies.
详细描述
In the recent guideline of World Society of Emergency Surgeons (WSES) recommendations regarding the clinical scoring systems for acute appendicitis are remarkable. It is stated that clinical scoring systems, on their own, can be used to exclude acute appendicitis and decrease negative laparotomy rates. Currently Appendicitis Inflammatory Response Score (AIR) and Adult Appendicitis Score (AAS) are the best clinically performing scoring systems. As a result, based on strong evidence the use of these two systems are recommended. Both scoring systems are developed on the basis of clinical findings and laboratory parameters.
The aim of this study is to validate both systems as well as to compare the efficiency of both systems on excluding negative laparotomies and on the determination of severity of acute appendicitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presenting to ER with right lower quadrant pain
- •Patients between 18-65 years old.
排除标准
- •Patients receiving immun-suppressive therapy
- •Patients with diagnosed malignancy
- •Presence of mental retardation
- •Patients with previous right hemicolectomy
- •Patients with previous appendectomy
- •Pregnant women
结局指标
主要结局
Exclude acute appendicitis
时间窗: 6 months
The ability of the scoring systems in detecting patients without acute appendicitis presenting with right lower quadrant pain to emergency service
Predicting the severity of acute appendicitis
时间窗: 6 months
The ability of scoring systems in predicting the rate of perforation in patients with acute appendicitis
次要结局
未报告次要终点
研究者
Alirıza Erdoğan
Principal Investigator
Nigde Omer Halisdemir University