Heart Failure With Mildly Reduced Ejection Fraction Registry (HARMER)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,200
- 试验地点
- 1
- 主要终点
- All-cause mortality
研究概览
简要总结
Heart failure (HF) affects about 1% of patients younger than 55 years, whereas the prevalence of HF increases > 10% in patients with at least 70 years of age. Despite HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), the clinical significance of HF with mildly reduced ejection fraction (HFmrEF) has gained more importance within the past years. Those patients are characterized by a left ventricular ejection fraction (LVEF) of 41-49%. However, within the current European guidelines, limited treatment recommendations in this subgroup of HF are yet available as a consequence of the limited number of studies in this field. The "Heart Failure With Mildly Reduced Ejection Fraction Registry" aims to characterize patients with HFmrEF and investigated the prognostic impact of interventional and pharmacological therapies in this subgroup of HF patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with HFmrEF (i.e., LVEF 41-49%)
- •Patients with at least 18 years of age
排除标准
- •Patients younger than 18 years of age
结局指标
主要结局
All-cause mortality
时间窗: 2 years.
All-cause mortality
次要结局
- Change of NT-pro BNP(2 years.)
- Change of LVEF(2 years.)
- Heart-failure related hospitalization(2 years.)
研究者
Michael Behnes
Prof. Dr. med. Michael Behnes
Universitätsmedizin Mannheim