MIND Food and Speed of Processing Training in Older Adults With Low Education, The MINDSpeed Alzheimer's Disease Prevention Pilot Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 212
- 试验地点
- 2
- 主要终点
- Executive Cognitive Function Composite Score
研究概览
简要总结
The purpose of this study is to learn how foods high in polyphenols and brain training exercises affect older adults' cognitive performance
详细描述
Adults with low education who give informed consent will complete a baseline cognitive assessment and then be randomized to one of four arms: 1) MIND foods and cognitive training, 2) MIND foods and control training, 3) control foods and cognitive training, or 4) control foods and control training.
All interventions are conducted through applications running on a tablet computer device that we will provide to all participants for the study duration. Cognitive training is delivered through the online BrainHQ program from Posit Science, Inc. The foods will be shown on the tablet device in an online shopping format. Selected foods will be prepared and delivered by the study team.
Active intervention will last for 12 weeks. After the 12-weeks, free food deliveries will cease but participants who were allocated to cognitive training will continue to have access to BrainHQ. Those in the MIND food arms will be encouraged to maintain MIND food consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
MINDSpeed Intervention
Consumption of foods high in polyphenols (i.e., MIND foods) AND speed of processing training
干预措施: MIND foods (Behavioral)
Control foods and speed of processing training
Consumption of low polyphenol foods AND speed of processing training
干预措施: Control foods (Behavioral)
Double Control
Consumption of low polyphenol foods AND online (inert) games
干预措施: Cognitive training control (Behavioral)
MINDSpeed Intervention
Consumption of foods high in polyphenols (i.e., MIND foods) AND speed of processing training
干预措施: Speed of processing training (Behavioral)
MIND food and training control
Consumption of foods high in polyphenols (i.e., MIND foods) AND online (inert) games
干预措施: MIND foods (Behavioral)
MIND food and training control
Consumption of foods high in polyphenols (i.e., MIND foods) AND online (inert) games
干预措施: Cognitive training control (Behavioral)
Control foods and speed of processing training
Consumption of low polyphenol foods AND speed of processing training
干预措施: Speed of processing training (Behavioral)
Double Control
Consumption of low polyphenol foods AND online (inert) games
干预措施: Control foods (Behavioral)
结局指标
主要结局
Executive Cognitive Function Composite Score
时间窗: Immediately following the 12-week intervention (Immediate Post-Training)]
Executive Cognitive Function Composite Score as Measured by Individually-Administered Tests of Verbal Fluency, Complex Sequencing, Response Inhibition, and List Learning. The scale score range is -20 to 20. Low scores represent worse function and higher scores represent better function.
次要结局
未报告次要终点
研究者
Daniel Clark
Associate Professor of Medicine
Indiana University