The Body's Response to Food Intake in Trained, Older Adults

Not Applicable

Completed

• Conditions: Elderly
• Interventions: Dietary Supplement: Liquid Supplements; Dietary Supplement: Solid Supplement

• Registration Number: NCT00798668
• Lead Sponsor: Purdue University

Brief Summary

The purpose of this research study is to determine the effects of food supplements and strength training on appetite, the amount of energy expended, and body composition.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09
• Primary Completion: 2007-08
• Study Completion: 2008-05
• Study First Submitted: 2008-11-25
• Study First Submitted QC: 2008-11-25
• Study First Posted: 2008-11-26
• Status Verified: 2010-03
• Last Update Submitted: 2013-09-23
• Last Update Posted: 2013-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

All subjects must meet the following eligibility criteria:

• Age range: 60 years and older
• Body mass index between 20-29 kg/m2
• Weight stable (< 2 kg weight change within last 6 months)
• Non-smoking
• Constant habitual activity patterns within last 3 months
• Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose <110 mg/dl)
• Not taking medications known to influence appetite or metabolism
• Non-diabetic
• Confirmation of acceptability of eating the study test foods (solids and fluids)

Trained subjects (Recruiting 36; N-25) must meet the following eligibility criteria:

• Resistive exercise training (≥ 2 times a week) based on reported physical activity levels (questionnaire)
• Active fitness level (≥ 2, 30-minute aerobic exercise sessions/week)

Sedentary subjects (Recruiting 36; N-25) must meet the following eligibility criteria:

• Resistive exercise training (≤ 1 time a week) based on reported physical activity levels (questionnaire)
• Active fitness level (≤ 2, 30-minute aerobic exercise sessions/week)

Exclusion Criteria

All subjects will be excluded based on the following exclusionary criteria:

• Age: <60 years
• Body mass index: outside of the 20-29 kg/m2 range
• Gained or lost > 4.5 kg within the last 6 months
• Smoker (currently or within the last year)
• Intermittently been involved in a diet and/or exercise program within the last 3 months
• Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
• Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
• Abnormal heart function (interpreted by a cardiologist) and assessed (for study exclusion) by our study physician, Arthur Rosen, MD
• Clinically diagnosed as diabetic
• Study foods are found to be unacceptable for consumption by the subject
• Clinically diagnosed osteoporosis

Trained subjects will be excluded based on the following exclusionary criteria:

• Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
• Perform ≤ 1, 30-minute aerobic exercise session/week (currently or within the last 3 months) based on physical activity levels questionnaire)

Sedentary subjects will be excluded based on the following exclusionary criteria:

• Performed resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
• Perform > 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels questionnaire)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Liquid Supplements	participants continue current exercise and take liquid supplement
2	Solid Supplement	Participants continue current exercise and take solid supplement
3	Liquid Supplements	Participants continue current sedentary behavior and take liquid supplements
4	Solid Supplement	Participants continue current sedentary behavior and take solid supplements

Primary Outcome Measures

Name	Time	Method
Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in trained and untrained, elderly people.	6 weeks

Secondary Outcome Measures

Name	Time	Method
Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and gastrointestinal transit time, to the differential appetitive responses to fluid versus solid foods in trained and untrained, elderly people	6 weeks

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States