NCT00798668已完成不适用
The Body's Response to Food Intake in Trained, Older Adults
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in trained and untrained, elderly people.
研究概览
简要总结
The purpose of this research study is to determine the effects of food supplements and strength training on appetite, the amount of energy expended, and body composition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All subjects must meet the following eligibility criteria:
- •Age range: 60 years and older
- •Body mass index between 20-29 kg/m2
- •Weight stable (< 2 kg weight change within last 6 months)
- •Non-smoking
- •Constant habitual activity patterns within last 3 months
- •Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose <110 mg/dl)
- •Not taking medications known to influence appetite or metabolism
- •Non-diabetic
- •Confirmation of acceptability of eating the study test foods (solids and fluids)
- •Trained subjects (Recruiting 36; N-25) must meet the following eligibility criteria:
- •Resistive exercise training (≥ 2 times a week) based on reported physical activity levels (questionnaire)
- •Active fitness level (≥ 2, 30-minute aerobic exercise sessions/week)
- •Sedentary subjects (Recruiting 36; N-25) must meet the following eligibility criteria:
- •Resistive exercise training (≤ 1 time a week) based on reported physical activity levels (questionnaire)
- •Active fitness level (≤ 2, 30-minute aerobic exercise sessions/week)
排除标准
- •All subjects will be excluded based on the following exclusionary criteria:
- •Age: <60 years
- •Body mass index: outside of the 20-29 kg/m2 range
- •Gained or lost > 4.5 kg within the last 6 months
- •Smoker (currently or within the last year)
- •Intermittently been involved in a diet and/or exercise program within the last 3 months
- •Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
- •Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
- •Abnormal heart function (interpreted by a cardiologist) and assessed (for study exclusion) by our study physician, Arthur Rosen, MD
- •Clinically diagnosed as diabetic
- •Study foods are found to be unacceptable for consumption by the subject
- •Clinically diagnosed osteoporosis
- •Trained subjects will be excluded based on the following exclusionary criteria:
- •Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
- •Perform ≤ 1, 30-minute aerobic exercise session/week (currently or within the last 3 months) based on physical activity levels questionnaire)
- •Sedentary subjects will be excluded based on the following exclusionary criteria:
- •Performed resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
- •Perform > 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels questionnaire)
结局指标
主要结局
Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in trained and untrained, elderly people.
时间窗: 6 weeks
次要结局
- Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and gastrointestinal transit time, to the differential appetitive responses to fluid versus solid foods in trained and untrained, elderly people(6 weeks)
研究者
Wayne Campbell
Professor, Foods and Nutrition
Purdue University
研究点 (2)
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