JPRN-UMIN000028139已完成未知
Therapeutic reactivity of Ustekinumab in moderate to severe active stage Crohn's disease - Therapeutic reactivity of Ustekinumab in moderate to severe active stage Crohn's disease
Graduate School of Medical Sciences, Kyushu University0 个研究点目标入组 27 人开始时间: 2017年7月7日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 27
研究概览
简要总结
The frequency of T helper 17 (Th17) cells was significantly decreased in the peripheral blood of patients with active CD after UST therapy, but not in the anti-TNF therapy. In addition, the changes in gene expression before and after UST and anti-TNF therapy were clearly different. From the above results, it was shown that the suppression of Th17 differentiation by UST therapy is associated with the anti-inflammatory effect on CD.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Patients with serious infection. 2) Patients with active tuberculosis. 3) Patients whose dosage of steroids is not stable (patients over 30 mg / day) 4) Patients with severe heart disease, liver disease, kidney disease. 5) Patients with marked blood coagulation disorders and thrombocytopenia. 6) Antithrombotic drugs Patients who are taking internal medicine and patients under anticoagulation therapy. 7) Pregnant women or patients who may be pregnant, breast-feeding patients. 8) Patients who are judged to be difficult to participate in the examination due to psychosis or psychiatric symptoms. 9) Patients with short bowel syndrome. 10) Patients who are judged inappropriate by the attending physician, such as a decline in compliance.
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