Retrospective Comparative Study of Routine Lower Neck CT in the Staging and Diagnosis of Lung Cancer Across Two Cohorts
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 164
- 主要终点
- Proportion of pathologically confirmed malignant supraclavicular lymph node
研究概览
简要总结
This is a study comparing routine inclusion of the lower neck in initial CT thorax in patients with suspected lung cancer to not including it. The study aims to assess whether such an intervention reduces the number of invasive investigations required to achieve a final diagnosis and clinical stage and whether it improves the detection of cervical lymph nodes involvement by lung cancer.
详细描述
Two practices currently exist regarding the role of lower neck CT in patients with suspected lung cancer but with little evidence for either. Routine lower neck CT is potentially associated with benefits of higher detection of neck lymphadenopathy leading to better staging, less invasive procedure with positive implications for patients experience and care. The potential harms are delay in diagnosis due to false positive findings and radiation exposure. There is limited evidence in this area so this study will potentially provide evidence to inform health policy decisions based on the risk benefit balance.
This is a retrospective comparative study to assess the real-life impact of routine lower neck CT on the diagnostic and staging work up of patients with suspected lung cancer across two cohorts.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female age > 18 years
- •Pathologically confirmed primary lung cancer
- •Intrathoracic N2 and or N3 disease on CT defined as lymph node with short diameter > 10 mm
排除标准
- 未提供
结局指标
主要结局
Proportion of pathologically confirmed malignant supraclavicular lymph node
时间窗: 60 days from initial CT
evidence of malignancy consistent with lung cancer on fine needle aspiration or core biopsy
次要结局
- Number of diagnostic procedures performed per patient(60 days from initial CT Thorax)
- Proportion of patients who underwent more than one diagnostic procedures(60 days from initial CT Thorax)
- Proportion of patients who underwent Endobronchial Ultrasound (EBUS)(60 days from initial CT Thorax)
研究者
Mohammed Ahmed
Fellow in interventional respiratory medicine
University College Hospital Galway