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临床试验/NCT03821584
NCT03821584终止不适用

Brain Perfusion Assessment in the Acute Phase of Migraine Aura.

Nantes University Hospital1 个研究点 分布在 1 个国家目标入组 25 人开始时间: 2019年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
25
试验地点
1
主要终点
Perfusion pattern of concerned brain areas

研究概览

简要总结

The aim of the study is to determine the proportion of patients with change in brain perfusion during the acute phase of migraine attack with aura.

详细描述

Migraine is a benign and frequent disorder. Migraine aura consists in reversible focal neurological symptoms developing gradually during attack. Its diagnosis relies mainly on patient's history, clinical examination and exclusion of other possible secondary causes to explain transient neurological signs. Thus it can be difficult particularly during first attack or during attack without headache to differentiate migraine aura from transient ischemic stroke. Considering the difference of care management and prognosis, an early distinction of migraine aura based on imaging techniques will have a particular interest. MRI with diffusion, SWI, Flair 2D, ARM 3D TOF, ASL sequences' are routinely performed for the management of acute neurological deficit. Arterial spin labeling (ASL), as a MR perfusion method, will be used to describe brain perfusion during migraine aura. The study hypothesis is that hyperperfusion occurs in brain territories corresponding to the neurological symptoms during migraine aura.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age between greater than or equal to 18
  • Able to undergo MRI during migraine aura

排除标准

  • Pregnant females
  • Contraindications towards MRI scanning
  • History of epilepsy, psychiatric disease, or any other neurologic disease (brain tumors, stroke..).
  • Presence of abnormalities on the MRI that could explain the neurological deficit.
  • Adults under guardianship or trusteeship

结局指标

主要结局

Perfusion pattern of concerned brain areas

时间窗: 1 hour

Presence or absence of hypo-hyperperfusion using arterial spin labeling. Visual assessments and comparison between hemispheres

次要结局

  • Pattern of perfusion and aura duration(12 month)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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