NCT02847052已完成不适用
Study of the Role of Soluble Inhibitor of Interleukin 22, Interleukin 22 Binding Protein (IL-22BP), in Chronic Inflammatory Bowel Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Regulation of Interleukine 22 binding protein expression in Crohn's disease or Ulcerative colitis
研究概览
简要总结
IL-22 is an IL-10 family cytokine that plays major actions to increase intestinal epithelial barrier function and regeneration during experimental colitis. IL-22 binding protein is a small, soluble, and secreted protein potently inhibiting IL-22 actions through preventing the binding with IL-22 Recepteur. This study aims at characterizing how IL-22 binding protein is regulated in Inflammatory bowel disease to better understand the way IL-22 acts on epithelial cells during flares of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Crohn's disease or Ulcerative colitis
- •Healthy controls paired for age and sex
- •Samples availability in the biobank
- •Signed consent
- •No (Immune Mediated Inflammatory Disorders other than Inflammatory bowel disease
- •No other conditions predicted or known to affect IL-22/IL-22 recepteur /IL-22 binding protein regulation
- •Availability of clinical data
- •Age >18 y.o.
- •No pregnancy
排除标准
- 未提供
结局指标
主要结局
Regulation of Interleukine 22 binding protein expression in Crohn's disease or Ulcerative colitis
时间窗: 1 day
次要结局
未报告次要终点
研究者
研究点 (1)
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