Effect of Amino Acids and Sugar Alcohols on Release of Satiation Peptides and Activation of Specific Brain Regions in Normal Weight and Obese Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Effect of aminoacids on cerebral blood flow measured by functional brain MRI
研究概览
简要总结
With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy normal weight subjects with a body-mass index of 19.0-24.9
- •Healthy obese subjects with a body-mass index of > 30
- •Normal eating habits (no diets; no dietary changes; no special dietary habits such as vegetarian/vegan)
- •Age 18-40 years
- •Stable body weight for at least three months
排除标准
- •Substance abuse
- •Regular intake of medications (except for oral contraceptives)
- •Medical or psychiatric illness
- •History of gastrointestinal disorders
- •Food allergies
- •Pregnancy, breast feeding
- •Body piercings that cannot be removed
- •History of claustrophobia
- •Left-hander
研究组 & 干预措施
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Tap water (Dietary Supplement)
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Tap water (Dietary Supplement)
Tap water and mixed liquid meal
300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Tap water (Dietary Supplement)
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Nasogastric Tube (Device)
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: 1.56 g L-Tryptophan (Dietary Supplement)
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) (Dietary Supplement)
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) (Dietary Supplement)
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Nasogastric Tube (Device)
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: 1.56 g L-Leucine (Dietary Supplement)
50 g Xylitol
50 g Xylitol in 300 mL tap water given via nasogastric tube
干预措施: 50 g Xylitol (Dietary Supplement)
50 g Xylitol
50 g Xylitol in 300 mL tap water given via nasogastric tube
干预措施: Nasogastric Tube (Device)
75 g Erythritol
75 g Erythritol in 300 mL tap water given via nasogastric tube
干预措施: 75 g Erythritol (Dietary Supplement)
75 g Erythritol
75 g Erythritol in 300 mL tap water given via nasogastric tube
干预措施: Nasogastric Tube (Device)
75 g Glucose and mixed liquid meal
75 g Glucose in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: 75 g Glucose (Dietary Supplement)
75 g Glucose and mixed liquid meal
75 g Glucose in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) (Dietary Supplement)
75 g Glucose and mixed liquid meal
75 g Glucose in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Nasogastric Tube (Device)
Tap water and mixed liquid meal
300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) (Dietary Supplement)
Tap water and mixed liquid meal
300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Nasogastric Tube (Device)
50 g Xylitol
50 g Xylitol in 300 mL tap water given via nasogastric tube
干预措施: Tap water (Dietary Supplement)
75 g Glucose and mixed liquid meal
75 g Glucose in 300 mL tap water given via nasogastric tube
- after 60 min: 500ml of a mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate) given via nasogastric tube
干预措施: Tap water (Dietary Supplement)
75 g Erythritol
75 g Erythritol in 300 mL tap water given via nasogastric tube
干预措施: Tap water (Dietary Supplement)
结局指标
主要结局
Effect of aminoacids on cerebral blood flow measured by functional brain MRI
时间窗: changes from baseline to one hour after treatment
Effect of sugar alcohols on cerebral blood flow measured by functional brain MRI
时间窗: changes from baseline to one hour after treatment
次要结局
- Measurement of Plasma PYY concentrations(changes from baseline to three hours after treatment)
- Measurement of Plasma ghrelin concentrations(changes from baseline to three hours after treatment)
- Measurement of Plasma Glucose concentrations(changes from baseline to three hours after treatment)
- Measurement of Plasma Insulin concentrations(changes from baseline to three hours after treatment)
- Measurement of Plasma cholecystokinin concentrations(changes from baseline to three hours after treatment)
- Measurement of Plasma Glucagon-like Peptide (GLP-1) concentrations(changes from baseline to three hours after treatment)