Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Normal Weight and Obese Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
研究概览
简要总结
With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy normal weight subjects with a body-mass index of 19.0-24.9
- •Healthy obese subjects with a body-mass index of > 30
- •Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
- •Age 18-40 years
- •Stable body weight for at least three months
排除标准
- •Substance abuse
- •Regular intake of medications (except for oral contraceptives)
- •Medical or psychiatric illness
- •History of gastrointestinal disorders
- •Food allergies
- •Pregnancy, breast feeding
研究组 & 干预措施
0.52 g L-Tryptophan
0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 0.52 g L-Tryptophan (Dietary Supplement)
0.52 g L-Tryptophan
0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 1.56 g L-Tryptophan (Dietary Supplement)
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 1.56 g L-Leucine (Dietary Supplement)
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
50 g Xylitol
50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 g Xylitol (Dietary Supplement)
50 g Xylitol
50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
75 g Erythritol
75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 75 g Erythritol (Dietary Supplement)
75 g Erythritol
75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
75 g Glucose
75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 75 g Glucose (Dietary Supplement)
75 g Glucose
75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
Tap water
300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 300 mL tap water (Dietary Supplement)
Tap water
300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
干预措施: 50 mg 13C-sodium acetate (Other)
结局指标
主要结局
Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
时间窗: changes from baseline to three hours after treatment
Plasma concentrations of glucose
次要结局
- Effect of different aminoacids and sugar alcohols on gastric emptying(changes from baseline to four hours after treatment)