Dose Response Effects of Soluble Corn Fiber (SCF) on Calcium Metabolism and Gastrointestinal Microflora in Adolescents
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Calcium Absorption
研究概览
简要总结
Soluble corn fiber (SCF) has been shown to enhance calcium utilization and bone properties in rats and in adolescent boys and girls.
详细描述
The growing knowledge of non-digestible oligosaccharide (NDO)-related health benefits has led to the identification of other fermentable carbohydrates which may improve bone balance and bone health parameters. One such carbohydrate is the corn derivative, soluble corn fiber (SCF). Already known for its association with improved intestinal health and influence on colonic microflora content, we have been studying the effects of SCF on calcium absorption and bone health. First we found that soluble corn fiber (SCF) greatly enhanced calcium utilization and bone properties in a growing rat model. Results from this study demonstrated that SCF was capable of increasing bone mineral content, density and bone strength parameters in 4-week old, male rats. Our study in adolescent boys and girls showed a 12% increase in calcium absorption after consuming 12 g SCF for 21 days compared to a control period in a crossover design using a controlled feeding metabolic balance approach. Given these profound changes on calcium absorption and in bone, a logical next step is to study a dose-response effect of SCF on calcium absorption, bone turnover, and gut microflora in free-living adolescents.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 9 Years 至 13 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy adolescent Caucasian girls between the ages of 12-
- •This population has been chosen because they exhibit higher risk for osteoporosis later in life.
排除标准
- •Habitual dietary patterns including less than 550 and greater than 1500 mg Ca per day. This represents the 5th and 95th percentile of usual intake of girls 9-13 y in the US.
- •History of smoking, alcohol use, illegal or non-prescription drug use
- •History of disordered calcium or bone metabolism e.g. Paget's disease, hyper or hypo-calcemia
- •History of gastrointestinal diseases (Crohn's, celiac, inflammatory bowel disease)
- •History of diseases that affect kidney or liver function.
- •Body Mass Index (BMI) less than 5th percentile for age or greater than the 90th percentile for age
- •Having a broken bone within the last 6 months.
- •Regular consumption of foods or supplements containing prebiotics or probiotics
- •History of pregnancy or use of contraceptives
结局指标
主要结局
Calcium Absorption
时间窗: 4 Weeks
The subject will be asked to consume one snack item in the morning and one snack in the evening for four consecutive weeks. After consuming the SCF product for four weeks the teen will come to Purdue University campus for 3 nights and days (e.g. Thursday noon - Sunday noon). They will reside in university residence hall or hotel near campus. Calcium Absorption testing will be done utilizing 43Ca and 44Ca.
次要结局
- GI microbial changes(4 weeks)
研究者
Berdine Martin
Research Scientist, Nutrition Science
Purdue University