Effectiveness of Rehabilitation (Phasic Alerting and Visual Spatial Scanning Training) on the Recovery of Patients Post Right Stroke With Unilateral Spatial Neglect: Using Functional Imaging PET and Standardized Neurobehavioral and Functional Tests
试验速览
- 阶段
- 2 期
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- This study's aim is to examine the functional reorganization of the attentional network in the brain of USN patients while performing visual tasks, by means of functional neuroimaging techniques, in light of specific rehabilitation techniques.
研究概览
简要总结
Unilateral spatial neglect (USN) is believed to be a disorder of attention, characterized by impairment in the ability to perceive or respond to stimuli presented to the contralesional space, and which is not attributable to significant sensory or motor deficits. USN has serious consequences for rehabilitation and long term disabilities. Efforts have been made to clarify both the theoretical basis of this phenomenon and the rehabilitation methods that will be best in improving function. The purpose of this study is to try and contribute to both efforts by examining treatment effectiveness of two methods; one targeting general arousal (phasic alerting), and the other targeting increasing awareness to left side stimuli and habit changes. Functional neuroimaging methods (PET [positron emission tomography] and fMRI [functional magnetic resonance imaging]) have been applied to understand the functional anatomy of the brain during mental processes. Only a few attempts have been made to use functional neuroimaging in patients with neurological deficits such as USN, usually speculations are made based on findings with healthy participants to explain this disorder. This study's aim is to examine the functional reorganization of the attentional network in the brain of USN patients while performing visual tasks, by means of functional neuroimaging techniques, in light of specific rehabilitation techniques.
Patients will be examined before and after 3 weeks of rehabilitation both using standardized neurobehavioral tests and PET imaging procedures.
详细描述
Procedure:
Inclusion criteria:
- first time right hemispheric stroke (ischemic);
- 2-6 weeks post stroke incident;
- ages 25-85;
- right hand dominance;
- minimum education of 6 years;
- do not suffer from field cut deficit such as hemi-anopsia;
- without other known neurological disorders (e.g., Parkinson's disease, aphasia);
- without severe systemic conditions (e.g., malignancies, AIDS, congestive heart failure, substance abuse);
- did not take additional medications that could affect the central nervous system; without dementia;
- without mental illness;
- the patients or their legal guardians have to give informed consent.
Participants:
- six patients will be recruited and randomly allocated to one of the treatment groups (phasic alerting or standard visual spatial training treatment provided in the OT department).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 25 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •First time right hemispheric stroke (ischemic)
- •2 - 6 weeks post stroke incident
- •Ages 25 - 85
- •Right hand dominance
- •Minimum education of 6 years
- •The patients or their legal guardians have to give informed consent
- •Does not suffer from field cut deficit such as hemi-anopsia
- •Without other known neurological disorders (e.g., Parkinson's disease, aphasia)
- •Without severe systemic conditions (e.g., malignancies, AIDS, congestive heart failure, substance abuse)
- •Does not take additional medications that could affect the central nervous system
- •Without dementia
- •Without mental illness
排除标准
- 未提供
结局指标
主要结局
This study's aim is to examine the functional reorganization of the attentional network in the brain of USN patients while performing visual tasks, by means of functional neuroimaging techniques, in light of specific rehabilitation techniques.
次要结局
- The aim of this study is to try and contribute to both efforts by examining treatment effectiveness of two methods; one targeting general arousal (phasic alerting), and the other targeting increasing awareness to left side stimuli and habit changes.