NL-OMON47966已完成不适用
The effect of acute whole-body heat exposure on liver insulin sensitivity and substrate metabolism - Heat and hepatic insulin sensitivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •* Signed informed consent
- •* Men and women
- •* Caucasian / white western European
- •* Aged 45-65 years at the start of the study
- •* Body mass index (BMI) 27-35 kg/m2
- •* Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3
- •* Stable sedentary lifestyle (not more than 2 hours of sports per week)
- •* Women after their menopause, meaning cessation of menses for at least 24
- •months) and only if they are not under hormonal treatment
- •* Suitable veins for cannulation or repeated venapuncture
- •* Generally healthy, no medication use that interferes with metabolism, no
- •signs of active cardiovascular disease, liver or kidney malfunction. If
- •volunteers need medication, it will be reviewed with the dependent physician on
- •individual basis.
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •* Type 2 Diabetes
- •* Men Haemoglobin <8.4mmol/L, women haemoglobin <7.8 mmol/L
- •* Signs of active uncontrolled hypertension, liver or kidney malfunction
- •* Cardiac problems and cardiovascular diseases, such as congestive heart
- •failure, angina pectoris, cardiac infarction and arrhythmias
- •* Any medical condition requiring treatment and/or medication that might
- •interfere with the investigated parameters. All medical conditions/medications
- •will be reviewed with the dependent physician and in-/exclusion will be decided
- •on individual basis
- •* Unstable body weight (weight gain or loss >3kg in the past three months)
- •* Participation in another biomedical study within 1 month prior to screening
- •* Participants, who do not want to be informed about unexpected medical
- •findings, or do not wish that their treating physician will be informed, cannot
- •participate in this study
- •* Blood donation three month prior to study and three month after finishing
- •* Alcohol consumption of >2 servings per day for men and >1 serving per day for
- •* Smoking in the past 6 months
- •A medical doctor will judge participation eligibility based on the medical
- •history questionnaire, medication use and fasting blood parameters. If the
- •medical doctor advises that someone cannot participate, they will be excluded
- •from enrolment.
研究者
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