Inflammatory Proteins,Gene Polymorphisms, and Transcriptome Profiles in Patients With Chronic Atrophic Acrodermatitis
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- inflammatory proteins in patients with chronic atrophic dermatitis
研究概览
简要总结
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with chronic atrophic dermatitis to gain better insight into pathogenesis of chronic infection with Borrelia burgdorferi sensu lato.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic atrophic dermatitis in patients >18 years
排除标准
- 未提供
研究组 & 干预措施
ACA-doxy 14 days
patients with chronic atrophic acrodermatitis treated with doxycycline for 14 days
干预措施: doxycycline orally, 100 mg, bid, 14 days (Drug)
ACA-doxy 28 days
patients with chronic atrophic acrodermatitis treated with doxycycline for 28 days
干预措施: doxycycline orally, 100 mg, bid, 28 days (Drug)
结局指标
主要结局
inflammatory proteins in patients with chronic atrophic dermatitis
时间窗: up to 24 months
The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses.
次要结局
- clinical characteristics of patients with chronic atrophic dermatitis treated with doxycycline for 14 or 28 days(at enrollment, at 2, 6 12 and 24 months follow-up)
研究者
Franc Strle
M.D., PhD
University Medical Centre Ljubljana