Exercise in Elderly Individuals With Impaired Glucose Tolerance: Beneficial for Vasculature and Neurons?
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Auditory Verbal Learning Task
研究概览
简要总结
The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
详细描述
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.
Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •subjects with impaired glucose tolerance
- •50-65 years old
- •moderate to heavy weight (BMI 25-35)
- •must be able to do exercise intervention
排除标准
- •younger than 50 years
- •BMI < 25
- •psychiatric medication
- •severe disease
- •MMSE < 26
- •severe cardiovascular disorders
研究组 & 干预措施
Exercise
干预措施: Exercise (Behavioral)
Placebo
干预措施: Exercise (Behavioral)
结局指标
主要结局
Auditory Verbal Learning Task
时间窗: Prior to intervention and after 6 months of intervention
次要结局
- Functional/Structural brain changes(Prior to intervention and after 6 months of intervention)
- Plasma biomarkers(Prior to intervention and after 6 months of intervention)
研究者
Agnes Flöel
Prof
Charite University, Berlin, Germany