Adiposity and Endothelin Receptor Function
试验速览
- 阶段
- 早期 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Percentage Change in Flow-Mediated Dilation (FMD)
研究概览
简要总结
Elevated levels of ET-1 have been implicated in cardiovascular disease and some forms of hypertension. Due to the strong, positive correlation between obesity and hypertension, the present study will explore the contribution of adiposity in ETB receptor function and aim to elucidate if ETB receptor dysfunction is a major contributor to hypertension in obesity.
详细描述
The proposed study is designed to investigate the influence of adiposity on ETB receptor function and subsequent vascular responses. The combination of ET-1, ET-3, and the respective ETA and ETB receptor antagonists will be used to provide insight into the mechanisms of ETB receptor dysfunction in the presence of adiposity. Previous studies have revealed elevations in circulating ET-1 in obese individuals; therefore, we predict that obese subjects will exhibit 1) ETB receptor dysfuncton compared to lean subjects and 2) an improvement in ETB receptor dysfunction following treatment with Candesartan.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •If you are an adult between the ages of 18-40 year old
排除标准
- •Evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease
- •Evidence of pregnancy
- •Using medications that affect vascular tone (i.e., nitrates, etc.)
- •Use of any anticoagulants (i.e. aspirin)
- •If you are postmenopausal
- •If you have uncontrolled hypertension (treated resting SBP >140 mm Hg or DBP >90 mm Hg)
研究组 & 干预措施
Candesartan
Sub chronic (7 days) Candesartan (16 mg/day)
干预措施: Candesartan (Drug)
Placebo
Endothelial function will be determined following a seven day treatment of placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Percentage Change in Flow-Mediated Dilation (FMD)
时间窗: pre-treatment Baseline and 7 days post-treatment
Change in Brachial artery FMD induced by reactive hyperemia assessed vascular endothelial function at baseline and several hours after treatment.
次要结局
未报告次要终点
研究者
Ryan Harris
Assistant Professor
Augusta University