NCT01212692已完成2 期
A Theoretically Based Memory Training Intervention in Mild Cognitive Impairment
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 2
- 主要终点
- Rey Auditory Verbal Learning Test
研究概览
简要总结
The purpose of this study is to learn if activities that challenge the brain (mentally stimulating activities) can improve memory and other types of thinking in patients with Mild Cognitive Impairment. The study will compare the effects of different methods of mental stimulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 50 years of age
- •meet criteria for amnestic-Mild Cognitive Impairment (MCI)
- •have capacity to give informed consent
- •have capacity to complete assessment measures
排除标准
- •history of drug or alcohol dependence
- •severe psychiatric conditions associated with psychosis (e.g., schizophrenia)
- •recent stroke
- •clinical diagnosis of probable Alzheimer's Disease
- •history of seizure disorder, serious head trauma, or other medical, psychiatric, or neurological conditions associated with significant cognitive impairment (e.g., Parkinson's Disease, Korsakoff's, HIV)
- •current use of Alzheimer's Disease medications (e.g., cholinesterase inhibitors, memantine)
结局指标
主要结局
Rey Auditory Verbal Learning Test
时间窗: 9 months post-intervention
Self-Ordered Pointing Task
时间窗: baseline
Trail-Making
时间窗: 9 months post-intervention
Timed Instrumental Activities of Daily Living
时间窗: 9 months post-intervention
Self-ordered pointing task
时间窗: 9 months post-intervention
次要结局
- Verbal Fluency Test(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Clinical Dementia Rating Scale(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Digit Symbol Substitution Test(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Digit Span(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- N-Back(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Instrumental Activities of Daily Living(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Neuropsychiatric Inventory(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Multifactorial Memory Questionnaire(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Geriatric Depression Scale(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Recollection Task(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Rivermead Behavioral Memory Test(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
- Functional Capacities for Activities of Daily Living(baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention)
研究者
Paul B. Rosenberg
Associate Professor
Johns Hopkins University
研究点 (2)
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