The Role of Brain Activation and Cerebral Blood Flow in Mental Fatigue.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Blood Oxygen Level Dependent - Signal during a 10-min cognitive task (i.e. Flanker task)
研究概览
简要总结
To assess the changes in brain activation and cerebral blood flow due to mental fatigue in a placebo-controlled study. More specifically we want to assess whether brain activation [measured with Blood Oxygen Level Dependent (BOLD) functional resonance imaging (fMRI)] is decreased during a Flanker task in a mentally fatigued state and whether this coincides with a decline in cognitive performance. In addition we also want to evaluate whether cerebral blood flow [measured with arterial spin labeled (ASL) fMRI] in a resting state is reduced when mentally fatigued.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy (No neurological/cardiorespiratory/psychological disorders)
- •No medication
- •Non-smoker
- •Between 18 and 35 years old
排除标准
- •Pacemaker, neurostimulator, medication pump or metal implants
- •Use of medication or any kind of drugs
- •Use of alcohol, caffeine and heavy efforts 24 hours before each trial
- •Not eating the same meal the night before and the morning of each trial
研究组 & 干预措施
Mentally fatiguing task
A modified Stroop task of 90 min, partitioned in 8 blocks of 252 stimuli, will be used as mentally fatiguing task.
干预措施: Mental fatigue (Other)
Control task
In the control task subjects will have to watch a documentary on the same computer screen as that used for the experimental trial for 90 min.
干预措施: Control (Other)
结局指标
主要结局
Blood Oxygen Level Dependent - Signal during a 10-min cognitive task (i.e. Flanker task)
时间窗: Blood Oxygen Level Dependent - Signal will be measured during a 10-min Flanker task that will be completed immediately prior and after the 90-min task that is completed in both trials.
Blood Oxygen Level Dependent - Signal will be measured during a 10-min Flanker task that will be completed immediately before and after the 90-min task (i.e. documentary in control trial; stroop task in intervention trial)
次要结局
未报告次要终点
研究者
Romain Meeusen
Principal Investigator
Vrije Universiteit Brussel