High Flow Nasal Cannula Compared to Continuous Positive Airway Pressure in the Treatment of Obstructive Sleep Apnea
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Obstructive Sleep Apnea
- 发起方
- Chung-Chieh, Yu
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Apnea Hypopnea Index
- 状态
- 已完成
- 最后更新
- 5年前
概览
简要总结
This study compare the efficacy of high flow nasal cannula with nasal continuous positive airway pressure. All of participants will be randomized to receive one night high flow nasal cannula therapy and another night for nasal continuous positive airway pressure.
详细描述
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common medical condition. Nasal continuous positive airway pressure (CPAP) is mainstay of treatment for OSAHS, but CPAP has some limitations. Patient who has bulbar dysfunction and poor consciousness are contraindications for CPAP. They are also not suitable for other therapy. There are still large number of patients could not accept CPAP. Alternative treatment method transnasal high flow was developed and previous study showed moderately reduce respiratory event. It is deliver 20 L/minute constant room air by nasal cannula. Because the technical limitation, the maximal flow rate is also 20 L/minute and it limit the effectiveness. Recently, new high flow nasal cannula(HFNC) is developed. This HFNC has already widely been used for respiratory disease. It can deliver air flow up to 60 L/mins. It is also can maintain high humidifier and adequate temperature. The every 10 L/min air flow could generate approximately 1 cmH2O positive end expiratory pressure (PEEP). The higher air flow could generate more high PEEP and may have better effect than previous HFNC, but there are no study to evaluate the efficacy in OSAHS patient. Thus, the purpose of our study is to compare the efficacy of HFNC with standard CPAP therapy. All of the participants were randomized into two groups for minimized first night effects. All of them would receive one-night HFNC therapy and another night for CPAP titration under PSG monitoring. The duration between these two treatments was approximately one week apart. The first group underwent CPAP titration on the first night and HFNC titration on the second night. Conversely, the second group was subjected to HFNC on the first night and CPAP titration on the second night. All of the participants were asked and recorded their side effects following completion of an HFNC or CPAP.
研究者
Chung-Chieh, Yu
Director of Sleep Center
Chang Gung Memorial Hospital
入排标准
入选标准
- •Apnea hypopnea index greater than 5 times per hour
- •Age greater than 18 years old.
排除标准
- •Central sleep apnea
- •Hypoventilation syndrome
- •Chronic obstructive airway disease
- •Receive soft palate surgery or used an oral appliance
- •Intolerance to transnasal high flow or CPAP
- •Pregnant women
- •Unstable hemodynamic state
- •Eastern Cooperative Oncology Group Performance Status higher than grade 2
结局指标
主要结局
Apnea Hypopnea Index
时间窗: 2 days
The Apnea Hypopnea Index(AHI) is an index used to indicate the severity of sleep apnea. It is represented by the number of apnea and hypopnea events per hour of sleep. The AHI under one night transnasal high flow therapy will be compared with one night continuous positive airway pressure.
Oxygen Desaturation Index
时间窗: 2 days
The oxygen desaturation index (ODI) is the number of times per hour of sleep that the blood's oxygen level drop by 3% degree from baseline.The ODI under one night transnasal high flow therapy will be compared with one night continuous positive airway pressure.
次要结局
- Sleep Efficiency(2days)
- Total Sleep Time(2 days)