Pilot Study: The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Endothelial (dys)function
研究概览
简要总结
High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.
Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Females to be postmenopausal and not on hormone replacement therapy
- •25 > BMI < 35
- •Sedentary to light activity lifestyle.
排除标准
- •History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc).
- •History of diabetes (Type 1 or type 2)
- •Vegan or with food allergies or intolerances.
- •Taking any antioxidants over the counter (Vit C, E or polyphenol supplements)
- •Taking prescription medication for hypertension.
研究组 & 干预措施
Red Wine + Meal
250 ml Red Wine and a high calorie, high fat meal (>900 kcal, 50g fat)
干预措施: Red Wine (Other)
Orange Juice + Meal
250 ml Orange Juice and a high calorie, high fat meal (>900 kcal, 50g fat)
干预措施: Orange Juice (Other)
Water + Meal
250 ml Water and a high calorie, high fat meal (>900 kcal, 50g fat)
干预措施: Water (Other)
Green Tea + Meal
250 ml Green Tea and a high calorie, high fat meal (>900 kcal, 50g fat)
干预措施: Green Tea (Other)
结局指标
主要结局
Endothelial (dys)function
时间窗: 2 hours post-prandial
Assessed via flow mediated dilatation
次要结局
- Plasma antioxidant capacity(2 hours post-prandial)
- Plasma ox-LDL(2 hours post-prandial)
- Plasma Nitrite(2 hours post-prandial)