FGF-21 During Physical Exercise in Patients With Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus and Healthy Controls
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- FGF-21 change after physical activity
研究概览
简要总结
FGF-21 and insulin are key hormones in the regulation of glucose metabolism. Furthermore, both hormones are influenced by physical activity. The following hypothesis will be tested: FGF-21 is regulated insulin-dependent during exercise.
详细描述
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by rising global importance. In Germany alone, more than seven million people are being treated currently. T2DM is characterized by permanently elevated blood glucose levels, based on insulin resistance and followed by associated beta cell failure. In our previous work the investigators could already shown that increased FGF-21 levels are accompanied by an increased risk of T2DM. Physical activity is essential in the treatment and the prevention of T2DM. Interestingly, it was shown that acute physical exercise was leading to decreased insulin levels and increased FGF-21 values. In this study the effects of acute physical activity on FGF-21 values should be investigated in 3 groups: a) Healthy volunteers b) persons with T2DM c) persons with T1DM.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers,persons with T2DM, persons with T1DM
排除标准
- •Patients with contraindications to an exercise ECG or spirometry be excluded from participation in the study.
研究组 & 干预措施
Healthy controls
Spiroergometry
干预措施: spiroergometry (Other)
Patients with T2DM
Spiroergometry
干预措施: spiroergometry (Other)
Patients with T1DM
Spiroergometry
干预措施: spiroergometry (Other)
结局指标
主要结局
FGF-21 change after physical activity
时间窗: FGF-21 before and 1 h after spiroergometry
次要结局
未报告次要终点
研究者
Knut Mai
FGF-21 and Exercise
Charite University, Berlin, Germany