Diagnosing and Monitoring Portal Hypertension Non-invasively Using Spleen Stiffness Measurement in Patients With Advanced Chronic Liver Disease: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Number of patients diagnosed with portal hypertension using elastography techniques
研究概览
简要总结
The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease. The main question it aims to answer are:
- what are the cut-off values for non-invasive tests (NITs) (including LSM, SSM) that predict the presence and occurrence of hepatic decompensation in individuals with advanced chronic liver disease?
Participants will undergo regular study visits involving non-invasive tests (LSM, SSM) and assessments to monitor hepatic decompensation over the study period.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 18years old
- •Advanced chronic liver disease (defined as LSM ≥ 10kPa)
- •Ability to provide informed consent
排除标准
- •Transjugular intrahepatic portosystemic shunt
- •previous liver transplantation
- •Abnormality of the porto-mesenteric system (portal vein thrombosis, splenic vein thrombosis, splenectomy, portal cavernomatous transformation, porto-caval shunts)
- •Hematological malignancy
结局指标
主要结局
Number of patients diagnosed with portal hypertension using elastography techniques
时间窗: At baseline
We will assess the diagnostic accuracy of liver and spleen stiffness measurements for portal hypertension
次要结局
- Identifying patients at high-risk of liver related events using elastography techniques(5 years)
研究者
Amine Benmassaoud
Division of Gastroenterology and Hepatology Assistant Professor of Medicine
McGill University Health Centre/Research Institute of the McGill University Health Centre