Remote Ischemic Preconditioning Effects on Kidney Function in Patients Receiving Transcatheter Aortic Valve Implantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- change in parameters determining renal function and injury
研究概览
简要总结
Patients with impaired renal function are at elevated risk for development of acute kidney injury (AKI). AKI is associated with increased risk for cardiovascular morbidity and mortality. Effective AKI prevention strategies are needed. Remote ischemic preconditioning (RIPC) is a novel and successful strategy to attenuate contrast medium induced AKI in patients undergoing elective coronary angiography.
The retrospective RenPro-TAVI Trial was designed to test the hypothesis whether remote ischemic preconditioning might attenuate kidney injury in patients receiving transcatheter aortic valve implantation (TAVI).
Patients with impaired renal function undergoing TAVI will be evaluated in respect whether they received remote ischemic preconditioning before the procedure or not. This study will give insight if RIPC might be beneficial in these patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >= 18 years
- •impaired renal function (baseline eGFR of <60 ml/min)
- •high INTEGER risk score > 11
- •high EuroSCORE (European system for cardiac operative risk evaluation)
排除标准
- •severe renal impairment (eGFR <15 ml/min and/or in chronic dialysis)
- •recent (<=30 days) contrast media exposure
- •patients enrolled in concomitant studies
- •fertile women
结局指标
主要结局
change in parameters determining renal function and injury
时间窗: 48 hours after TAVI
serum creatinine, cystatin c, urinary neutrophil gelatinase-associated lipocalin (NGAL)
次要结局
- acute kidney injury(48 hours after TAVI)
研究者
Dr. Fikret Er
Associate Professor
University of Cologne