Comparison of the therapeutic effect of 5% ibuprofen nanoemulsion gel and commercial ibuprofen gel on knee osteoarthritis pain

Tehran University of Medical Sciences0 个研究点目标入组 124 人开始时间: 待定最近更新: 2021年4月26日

适应症

试验速览

暂无简介。

•Unilateral or bilateral knee osteoarthritis with radiographic evidence according to American College of Rheumatology criteria and the International Osteoarthritis Research Society which is diagnosed through physical examination by the physician
•Having mild to moderate knee osteoarthritis pain
•Written informed consent to participate in the study

•Very severe knee pain
•Recent lower limb injury or surgery such as repair and joint replacement
•Inflammatory arthritis
•Metabolic bone disease
•Fracture and/or dislocation of knee
•History of an open wound in the affected knee
•History of adverse reactions to NSAIDs
•Diabetes and Lupus disease
•Corticosteroid injection into the knee within 30 days of intervention
•Multiple sclerosis (MS)
•The dermatologic disorder which affected the surrounding skin of the knees
•Uncontrolled heart failure
•High blood pressure
•Chronic renal failure
•Respiratory diseases
•History of alcohol or drug abuse
•History of neurological disorders affecting sensory, motor or cognitive function

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