Precision Medicine Study on Cardiovascular Disease (PRECISE)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20,000
- 试验地点
- 1
- 主要终点
- number of participants with cardiovascular deaths
研究概览
简要总结
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model. A new and sustainable medical model is needed to solve this dilemma, for which precision medicine models have great potential. Monogenic cardiovascular disease is the first field to be broken through in precision medicine at this stage, and it is also the field where precision medicine is most likely to be successfully transformed into clinical application, including genetic diagnosis, molecular typing, risk stratification, genetic interruption and individualized treatment.
详细描述
In this study, patients with monogenic cardiovascular disease are recruited prospectively after informed consent was given. The investigator will collect the baseline clinical characteristics of the patients at enrollment, including comprehensive physical examination, laboratory testing of blood and urine, electrocardiography, 24-hour Holter, echocardiography, MRI and other examinations if necessary. The specimens retained include blood, saliva, urine and feces for all patients, and myocardium for patients receive cardio myectomy surgery . Genetic testing will be performed to identify novel disease genes, genetic risk factors and potential therapy targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with monogenic cardiovascular diagnosed according current practice guideline.
排除标准
- •Patients who refuse to sign the informed consent or decline follow-up.
结局指标
主要结局
number of participants with cardiovascular deaths
时间窗: an average of 5 years
including sudden cardiac death and deaths due to heart failure and stroke.
number of participants with all-cause death
时间窗: an average of 5 years.
deaths due to all cause.
次要结局
- number of participants with stroke(an average of 5 years)
- number of participants with malignant arrhythmia(an average of 5 years)
- number of participants with heart failure(an average of 5 years)
研究者
Lei.Song@NCCD
Principal Investigator
China National Center for Cardiovascular Diseases