CTRI/2022/09/045432尚未招募不适用
Attenuation of stress response to laryngoscopy and intubation with transdermal buprenorphine patch under general anesthesia
Mahatma Gandhi University Of Medical Sciences And Technology1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2022年9月15日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- to observe any changes in systolic blood pressure after laryngoscopy and intubation.
研究概览
简要总结
Altered hemodynamic response during laryngoscopy and intubation can cause many complications like left ventricular failure,myocardial infarction and pulonary edema etc.Oral or iv intravenous medications used to prevent stress response have been associated with many undesirable adverse effects like respiratory depression,drowsiness ,nausea and vomiting etc.Rationale for study is that transdermal buprenorphine would attenuate the stress response with no or minimal side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patient posted for surgery under general anaesthesia
- •patient with American Society of anaesthesiologists (ASA) Class I and II
- •patient of any sex (male or female) aged between 18-60 years
- •patient who give consent to involve in study.
排除标准
- •ï‚·Patient with American Society of Anaesthesiologists (ASA) Class III and IV ï‚·Patient allergic to buprenorphine ï‚·Patients with anticipated difficult intubation (Modified mallapatti score 3 or more) 1.More than one attempt at intubation 2.When intubation time exceeds 30 seconds 3.Patients with severe cardiopulmonary compromise 4.Pregnant female 5.Patients with liver and kidney disease 6.Patient refusal.
结局指标
主要结局
to observe any changes in systolic blood pressure after laryngoscopy and intubation.
时间窗: preoperatively and postoperatively
次要结局
- to observe changes in diastolic blood pressure,mean areterial pressure, and ecg(preoperatively and intraoperatively)
研究者
研究点 (1)
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