Quality of life among Children on Dialysis and effect of Omega 3 Fatty Acid Supplementation
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 31
研究概览
简要总结
Children with End Stage Renal Disease (ESRD) are liable to have poor quality of life. This work aimed to assess quality of life and study the effect of omega-3 fatty acid (?-3 FA) supplementation among children on dialysis. A pilot study was conducted on 31 hemodialysis children and an equal number of matched controls. Nonpharmacological treatments include dietary supplementation with ?-3 FA had been given to the patients for 16 weeks. PedsQL Measurement Model to measure quality of life (QOL) and laboratory investigations to assess the condition had been carried out. Patients had poorer QOL in comparison with controls especially regarding health activities (P<0.001). Poor QOL was reported among females and ages <12y (P<0.05). After ?-3 FA supplementation, the scores get improved not to the degree of controls scores but it showed some improvement (P<0.05). Lipid profile, inflammatory markers and efficiency of dialysis showed improvement (P<0.05). QOL among children on dialysis is affected by the disease. Beneficial effects of ?-3 FA were detected in children on dialysis reflected on improved quality of life. Further application on large sample to allow routine use for those patients is needed.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 6 Year(s) 至 12 Year(s)（—）
- 性别
- All
入选标准
- •Children with ESRD with
- •- A glomerular filtration rate of less than 10 ml/min/1.73 m2
- •- Age less than 14 years, and
- •- Regular hemodialysis at least three sessions per week for at least 3 months before the study will be included in the study.
排除标准
- •Patients with
- •- Pre-dialysis stages of CKD,
- •- On chronic peritoneal dialysis,
- •- Regular hemodialysis < 3 months,
- •- Primary (non-uremic) cardiovascular disease will be excluded from the study.
- •Forty nine patients were enrolled, 31 patients (17 males and 14 females, aged from 8-14 years) fit the inclusion criteria while 18 patients were excluded (due to exclusion criteria, acute infection, hospitalization, febrile illness and non-compliance).