Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on the Anti-nociceptive Criteria of Post-operative Opioid in Orthopedic Upper Limb Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Effect of ultra-low dose naloxone on the post operative opioid
研究概览
简要总结
Effective post-operative pain control can reduce patient morbidity and affect the patient outcome. Brachial plexus block is one of them, a popular and widely employed regional nerve block technique for perioperative anesthesia and analgesia for surgery of the upper extremity.
Different drugs have been used as adjuvants with local anesthetics in brachial plexus block to achieve quick, dense and prolonged block like Morphine, Pethidine, Clonidine, Dexmedetomidine.
Naloxone is opioid antagonists which could selectively block the excitatory effects of opioids. it release endorphins and also displace endorphins from receptor site .it also reduce the opioid induced side effects, such as vomiting, nausea, pruritus, and respiratory depression.
详细描述
The aim of this study is to evaluate the effect of ultra-low dose of naloxone when added to bupivacaine %.05 in supraclavicular brachial plexus block in orthopedic upper limb surgery and if it enhances the anti-nociceptive effect of post-operative opioid
Effect of naloxone on anti-nociceptive criteria of post -operative opioid will be estimated by detecting the interval between each analgesic dose of post-operative opioid.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiology (ASA) physical state class Ι and II
- •Elective upper limb orthopedic surgery (hand, forearm and elbow)
- •Duration of surgery ≤180 min
- •BMI ≤30 kg/m2
排除标准
- •History of allergy to the drug of the study.
- •Coagulation disorders
- •Infection at the puncture site.
- •Pregnancy
- •Opioid abuse.
- •Abuse of tranquilizers
研究组 & 干预措施
Bupivacaine plus naloxone
Patients will receive brachial plexus block using bupivacaine plus naloxone.
干预措施: Bupivacaine plus naloxone (Drug)
Bupivacaine
Patients will receive brachial plexus block using bupivacaine.
干预措施: Bupivacaine (Drug)
结局指标
主要结局
Effect of ultra-low dose naloxone on the post operative opioid
时间窗: for 48 hours after surgery
by estimate the analgesic requirements of opioids and the interval between each opioid dose in 48 hour post operative
次要结局
- Duration of sensory block(For 48 hours after surgery)
- Duration of motor block(For 48 hours after surgery)
- Onset time of sensory block(For 48 hours after surgery)
- Onset time of motor block(For 48 hours after surgery)
- Severity of post-operative pain(For 48 hours after surgery)
- 1st time of analgesic request(For 48 hours after surgery)