Comparative Study Between Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Probing Pocket depth
研究概览
简要总结
The aim of this study is to compare bovine bone with or without concentrated growth factor in the treatment of chronic periodontitis.
详细描述
Periodontitis is an infection-driven inflammatory disease resulting from dental plaque accumulation at the gingival margin, triggering an inflammatory response that leads to microbial alterations and may have severe consequences for the periodontium of susceptible individuals.
The xenograft most commonly used in periodontal regeneration procedures is the deproteinized bovine or equine bone mineral.
Platelets are known to play a significant role in guided tissue regeneration (GTR) by releasing several growth factors, such as platelet-derived growth factor (PDGF), and plasma rich in growth factors (PRGF), which are present in platelet-rich plasma (PRP), a first-generation platelet concentrate. Platelet-rich fibrin (PRF) and concentrated growth factors (CGF) are considered the second generation of platelet concentrate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of angular periodontal intra-bony defects with a pocket depth (PD) ≥ 5mm.
- •Optimal compliance as evidenced by no missed treatment appointments and a positive attitude towards oral hygiene.
- •Full-mouth bleeding score ≤ 25%.
排除标准
- •Patients with relevant medical conditions that may affect periodontal regeneration and periodontal surgery.
- •Patients who have any disease or take any medication that affects the normal number or function of platelets.
- •Pregnant or lactating women.
- •Patients in whom periodontal surgery had previously been carried out on the selected site.
- •Patients with aggressive periodontitis.
研究组 & 干预措施
Group Ι
Ten sites were treated by concentrated growth factors (CGF), collagen membrane, and xenograft bone graft.
干预措施: Concentrated growth factors, collagen membrane and xenograft bone graft (Other)
Group ΙΙ
Ten sites were treated with a collagen membrane and a xenograft bone graft.
干预措施: Collagen membrane and xenograft bone graft (Other)
结局指标
主要结局
Probing Pocket depth
时间窗: 6 months post-procedure
Probing Pocket depth (PPD) was measured.
次要结局
- Clinical attachment level(6 months post-procedure)
- Bleeding on probing(6 months post-procedure)
- Plaque index(6 months post-procedure)
研究者
Nouran Elsayed Elbadawy
B.D.S of Oral Medicine, Periodontology, Oral Diagnosis & Oral Radiology, Faculty of Dentistry, Tanta University, Tanta, Egypt.
Tanta University