Injectable Platelet Rich Fibrin (I-PRF) With Xenograft in Intrabony Defects of Periodontitis Patient Stage III Versus Xenograft Alone
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Radiographic parameters
研究概览
简要总结
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
详细描述
All surgical procedures will be conducted by a single operator. Following administration of local anesthesia, intrasulcular incisions will beperformed buccally and lingually/palatally on the affected tooth and extended one adjacent tooth mesially and distally, using 15c blades. Following mucoperiosteal flap elevation, thorough debridement will be performed using ultrasonic scalers and curettes until defects are clear from any granulation tissue, and the defect morphology will be visually explored and recorded. In the group1: xenograft alone(Bovin xenograft)will be applied to the intrabony defect area. In the group 2: xenograft (Bovin xenograft) with injectable platelet Rich fibrin (I- PRF) will be applied to the intrabony defect area. Preperation of Injectable platelate Rich Fibrin (I-PRF) : will be prepared for each patient as follows: 5 ml of venous blood will be collected from the patient blood then placed in a plastic tube without any added material or coagulant and centrifuged at 700 rpm for 3 min. then mixed with Xenograft. Finally, the flap will be passively repositioned using interrupted 4-0 silk
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient should have localized Periodontitis stage III grade B with pocket depth ≥ 6mm; indicated for periodontal surgery
- •Patient's agreement to the surgical procedure and clinical trial.
- •Age ranged between 30-55 years old.
- •Intrabony defects with depth ≥3mm.
- •Free from any systemic conditions and no previous drug affect bone metabolism
排除标准
- •Pregnant women.
- •Patients in variation in anatomical landmarks.
- •Patients with psychological problems.
- •Patients with abnormal habits.
结局指标
主要结局
Radiographic parameters
时间窗: 6 months after treatment
• The bone fill after 6 months postoperatively using digital periapical radiography using parallel technique.
次要结局
- Clinical attachment level (CAL)(pre-surgically 3 months and 6 months respectively)
- Gingival index (GI)(pre-surgically 3 months and 6 months respectively)
- Pocket depth (PD)(presurgically, 3 and 6 months interval after treatment)
- Plaque index (PI)(pre-surgically 3 months and 6 months respectively)
- Gingival index (GI)(pre-surgically 3 months and 6 months respectively)
- Clinical attachment level (CAL)(pre-surgically 3 months and 6 months respectively)
研究者
Ola Alsareh
Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department Faculty of Dental Medicine for Girls Al-Azhar University
Al-Azhar University