Acute Effects of Cricket Fast Bowling on Bone Turnover and Signaling Markers
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
研究概览
简要总结
The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males.
The main question aims to answer:
• Does a single bout acute fast bowling change serum C-terminal telopeptide of type I collagen (CTX-I) and other bone turnover and signaling markers levels?
Participants complete both the bowling and control trials, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 2-hour post bowling/rest.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male
- •Aged 18 - 30
- •Cricket fast bowlers (a ball speed of ~100kmh) playing for a university team or above, such as British Universities and Colleges Sport (BUCS) or University Centre of Cricketing Excellence (UCCE)
- •Injury free for the last 3 months
排除标准
- •Diagnosed with any disease or use of any medication that affects bone turnover
- •Fracture experienced within the previous year/season
研究组 & 干预措施
Arm Bowling + Control
Participants first perform the bowling trial, followed by the control trial, with a minimum interval of one week between the two trials.
干预措施: Exercise (Behavioral)
Arm Control + Bowling
Participants first perform the control trial, followed by the bowling trial, with a minimum interval of one week between the two trials.
干预措施: Exercise (Behavioral)
结局指标
主要结局
Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
时间窗: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum CTX-I concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
次要结局
- Serum N-terminal propeptide of type I collagen (PINP) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum parathyroid hormone (PTH) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum sclerostin concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum osteoprotegerin (OPG) concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Serum irisin concentration(Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.)
- Bowling speed(Bowling speed is measured during the bowling trial.)
研究者
Katherine Brooke-Wavell
Professor
Loughborough University