Evaluation of the Presence of a Double Anaerobic Threshold in a Population of Athletes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 3
- 主要终点
- Athletes groups
研究概览
简要总结
During an incremental cardiopulmonary exercise test (CPET) performed with a ramp protocol, it is very important to determine the anaerobic threshold, defined as the point at which the metabolism switches from being predominantly aerobic to also being anaerobic. The anaerobic threshold can be determined invasively, by identifying the increase in blood lactates with an arterial sampling, or, more commonly, non-invasively by three methods: the V-slope method, the ventilatory equivalents method and by using end-expiratory oxygen and carbon dioxide pressure (PETO2 and PETCO2 respectively). Normally, the anaerobic threshold is determined by the first method and the other two are used to confirm the value. The finding of different anaerobic threshold values using these three methods has been reported anecdotally in the past, while a prevalence of 11% in a healthy population has recently been described. Regular training, particularly that aimed at endurance sports, is able to shift the anaerobic threshold to higher exercise intensities. At present, the physiological reasons for the presence of a double threshold are unclear.
The aim of the study is to identify the anaerobic threshold by means of the V-slope method and by means of the ventilatory equivalents method in athletes who have performed an incremental ramp CPET at the laboratories of the investigating centres, to assess in how many athletes a double threshold is present and to try to interpret the physiological/ pathophysiological significance of this finding.
In this retrospective and prospective observational study, healthy male and female athletes who have had a cardiopulmonary test at our laboratories from 2007 to the present (retrospectively recruited) and prospectively recruited until the calculated sample size is reached will be enrolled.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •no major present or past illnesses, no ongoing treatment
- •At least 2 training sessions per week.
排除标准
- •Current illnesses and treatments for any physical condition that could potentially alter performance
- •Subjects who have performed a submaximal test (RER < 1.05)
- •CPET during which the AT determination is poorly assessable, i.e. due to changes in respiration.
- •obese subjects (BMI >30)
结局指标
主要结局
Athletes groups
时间窗: immediately after the incremental cardiopulmonary exercise test evaluation
Identification of two groups of athletes (those with identified double anaerobic threshold and those without)
次要结局
- Groups differences in age(immediately after the incremental cardiopulmonary exercise test evaluation)
- Groups differences in sport practised(immediately after the incremental cardiopulmonary exercise test evaluation)
- Groups differences in exercise performance(immediately after the incremental cardiopulmonary exercise test evaluation)
- Groups differences in VO2(immediately after the incremental cardiopulmonary exercise test evaluation)
- Groups differences in VE/VCO2 slope(immediately after the incremental cardiopulmonary exercise test evaluation)
- Groups differences in VE(immediately after the incremental cardiopulmonary exercise test evaluation)
- Differences in VO2 at the two thresholds(immediately after the incremental cardiopulmonary exercise test evaluation)
- Differences in VE/VCO2 at the two thresholds(immediately after the incremental cardiopulmonary exercise test evaluation)
- Differences in VE at the two thresholds(immediately after the incremental cardiopulmonary exercise test evaluation)