Neuromodulation and Language Acquisition (KS-Neuromod_01, Stage Ib)
试验速览
- 阶段
- 4 期
- 状态
- 暂停
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Boost in language learning success (percent hits) through neuromodulation
研究概览
简要总结
The purpose of this study is to determine whether rivastigmine or pramipexol are effective in boosting semantic language acquisition in healthy subjects.
详细描述
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether a selective d2/d3 dopamine agonist (pramipexole) or cholinergic neuromodulation (rivastigmine), after a titration period of five days, will yield a learning enhancement comparable to using levodopa in healthy subjects. The expected scientific results will strengthen the basis for transferring neuromodulatory interventions from the laboratory to stroke patients with language dysfunctions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects
- •20-35 years old
- •Right handedness
- •Left language dominance (as assessed by functional transcranial Doppler ultrasonography [fTCD])
排除标准
- •Neurological/psychiatric/metabolic/cardiac disorders
- •Known allergic reactions to one of the experimental drugs
- •Other drugs affecting the central nervous system
- •Leisure drug ingestion during the past 4 weeks (urine test)
- •Smoking cessation during the past 2 weeks
- •> 6 cups of coffee or energy drinks per day
- •> 10 cigarettes per day
- •> 50 grams of alcohol per day
结局指标
主要结局
Boost in language learning success (percent hits) through neuromodulation
次要结局
- Stability of language learning success after one week, one month, and one year