Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- evaluate the recording of fast ripples (FRs) and single neuron activity in the brain with the micro tetrodes
研究概览
简要总结
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
详细描述
This study would improve the localization of the epileptogenic zone and reduce the overall duration of monitoring, especially in patients who do not experience a sufficient number of seizures during the implantation period. In addition, it would be possible to use micro-electrodes and propose a better surgical treatment to some patients whose preliminary assessment with macro-electrodes has not provided significant results. Finally, the data collected during this study will help us to further understand pathological brain activity and to describe the neuronal circuitry that gives rise to cortical signals and the relationships between them (from spindles to high frequency oscillations).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •inclusion criteria is determined based on the clinical diagnosis of the refractory epilepsy and the admissibility of the patient for the stereoelectroencephalography (sEEG) procedure
排除标准
- •severe psychiatric disorders,
- •severe agitation during their crisis
- •contraindication for performing an MRI: claustrophobia, a cardiac or neural stimulator, ferromagnetic surgical clips, cochlear implants, intraocular metallic foreign body or in the nervous system,
- •contraindication to intracerebral investigation (macro-electrodes): ongoing infection, severe associated pathology (cardiac, pulmonary, renal, hepatic), pregnant or nursing women,
- •anti thrombotic ongoing treatment.
结局指标
主要结局
evaluate the recording of fast ripples (FRs) and single neuron activity in the brain with the micro tetrodes
时间窗: 1 week after implant
sum of number of single units recorded and the number of fast ripples (FRs)
次要结局
- Efficiency of microelectrodes compared to macroelectrodes(10 days after implant)
研究者
Adrien Peyrache
Associate Professor
McGill University