PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 152
- 试验地点
- 2
- 主要终点
- the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU
研究概览
简要总结
The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and discontinuation of CRRT, is a predictive finding to optimize the withdrawal time of renal support
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 18 years;
- •diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)
- •need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice
- •Obtaining informed consent
排除标准
- •CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care;
- •need for RRT (any type and modality) in the 14 days prior to enrolment;
- •diagnosis of AKD/CKD/ESRF on admission;
- •Discontinuation of CRRT under conditions that do not comply with the criteria established by the study;
- •Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);
- •pregnant women;
- •presence of known thyreopathy
- •Continuous use of corticosteroids
- •patient with known neoplastic disease.
结局指标
主要结局
the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU
时间窗: From enrlollment to the weaning from CRRT and 14 days after
To verify whether the change in plasma concentration of c-cistatin between initiation and discontinuation of CRRT is a predictive finding in patients with acute kidney injury admitted to the ICU It is measured as (cistatin at weaning minus cistatin basal) divided by cistatine basal, in percentage
次要结局
未报告次要终点