Comparison of Factor XII Levels in Gestational Diabetic and Healthy Pregnancies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Factor XII level
研究概览
简要总结
To compare Factor XII levels in gestational diabetic and healthy pregnancies.
详细描述
Thirty singleton term pregnant women with a diagnosis of Type I, Type II or gestational diabetes and thirty singleton uncomplicated term healthy pregnant women will be included in our study. Our study will be performed at Istanbul Acibadem Maslak Hospital, Turkey. Blood will be drawn from each patient when they are hospitalized and before they deliver either vaginally or by cesarean section. Blood will be drawn into two citrate tubes, each will contain 4 ml blood. Blood will be transferred to the lab immediately and will be centrifuged. The supernatant will be stored at -80°C. When the anticipated number of samples are completed Factor XII levels will be calculated in each sample.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Term pregnancy
- •Pregnant patients with a diagnosis of Type I diabetes
- •Pregnant patients with a diagnosis of Type II diabetes
- •Pregnant patients with a diagnosis of Gestational diabetes
- •Non-diabetic pregnancies
- •Uncomplicated pregnancies
排除标准
- •Preterm pregnancy
- •Postterm pregnancy
- •Pregnant patients with a diagnosis of systemic diseases other than diabetes
- •Complicated pregnancies
结局指标
主要结局
Factor XII level
时间窗: Blood will be drawn when the patient is hospitalized before they deliver.
The primary outcome is to evaluate Factor XII level in diabetic pregnancies. If the investigators can prove that Factor XII, which has a mitogenic activity and can increase the risk for thrombosis, increases more in diabetic pregnancies in the future usage of Factor inhibitors may reduce macrosomia, thrombosis and the complications due to these conditions in diabetic pregnancies
次要结局
- Macrosmia(Blood will be drawn when the patient is hospitalized before they deliver.)
研究者
Esra Ozbasli
Ass. Prof.
Acibadem University