Evaluation of the Demineralizing Effect on Enamel Surface During Orthodontic Treatment With and Without the Addition of Casein Phosphopeptides-Amorphous Calcium Phosphate (CPP-ACP) on: A Randomized Clinical Trial, Split Mouth Design
试验速览
- 阶段
- 1 期
- 入组人数
- 45
- 主要终点
- Effect on enamel surface color
研究概览
简要总结
This study is aiming in preventing the formation of WSL associated with orthodontic treatment which occurs to more than 50% of orthodontically treated patients through applying CPP-ACP on the enamel surface once every 2 weeks for 3 months.
详细描述
CPP-ACP will be applied on premolars to be extracted in orthodontic patients whose treatment plan indicates extraction of at least 2 premolaes of the maxillary arch. Application will continue on one premolar either the right or left one once every 2 weeks for the first 3 months of the treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •severe crowding
- •Increased overjet
- •Protruded maxillary base
- •Sound maxillary premolars
- •medically free
- •molar classification class II
- •Canine classification class II
排除标准
- •spacing of teeth
- •Decreased overjet
- •Molar classification III Medically compromised patients
- •pregnant females
- •carious premolars
- •hypoplasia
研究组 & 干预措施
CPP-ACP
Casein phosphopeptide amorphous calcium phosphate dental paste
干预措施: Casein Phosphopeptide-Amorphous Calcium Phosphate Dental Paste (Drug)
结局指标
主要结局
Effect on enamel surface color
时间窗: 3 months
Assessment of the effect of CPP-ACP on enamel surface using ICDAS-II
Effect on enamel surface
时间窗: 3 mnths
Assessment of the effect of CPP-ACP on enamel surface using visual analogue scale through digital photograph
次要结局
- Surface texture(3 months)
- Microhardnes(3 months)
研究者
Maha Abd El-Monem Nasr
Doctor
Cairo University