NCT02376127已完成不适用
Evaluation of Metastatic Spinal Bone Marrow Response to Radiation Therapy Using T1 Weighted Dynamic Contrast-Enhanced Perfusion
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- response to treatment
研究概览
简要总结
The purpose of this study is to assess imaging methods including Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) and perfusion for the cancer that has spread to the spine. The study aims to see if using these methods will help better see response to treatment with radiation in patients with spine metastases from any solid cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients 18 years of age or older
- •Known pathological diagnosis of any solid cancer.
- •Metastatic spinal lesions 1 cm or greater in diameter.
- •Patients who are already eligible for and are to be treated with hypofractionated or single dose radiation for their spinal lesions.
- •Note: The patients must have their treatments at MSKCC.
排除标准
- •Patients with renal failure or history of allergic reaction to Gadavist will be excluded.
- •Patients who would be normally excluded from undergoing an MRI examination as per Memorial Hospital for Cancer and Allied Disease Screening Questionnaire for MRI.
- •Patients with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field.
- •Patients with inability to cooperate for an MRI exam due to claustrophobia or high levels of anxiety.
- •Female patients who are pregnant or nursing.
- •Patients with eGFR < 30 are not eligible to higher risk of NSF.
结局指标
主要结局
response to treatment
时间窗: 2 years
will be based on clinical assessment and conventional MRI and PET imaging, evaluating images for evidence of tumor contraction and stable disease for more than 11 months. Clinical assessment is done by radiation oncology and is based on physical examination, patient symptoms and consideration of radiological studies.
次要结局
未报告次要终点
研究者
研究点 (1)
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