The Influence of Physical Training in Normobaric Hypoxia on Prooxidant-Antioxidant Imbalance, Inflammatory Marker Levels, Intestinal Damage Degree, and Mitochondrial Energy Release Rate in Young Non-trained Males
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Blood analysis
研究概览
简要总结
- Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males.
- Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 29 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.
排除标准
- •changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.
结局指标
主要结局
Blood analysis
时间窗: 7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts.
Indicators of prooxidant-antioxidant imbalance, markers of inflammatory status, markers of muscle damage, markers of intestinal damage, HIF (hypoxia-inducible factor), EPO (erythropoietin), markers of mitochondrial metabolism, morphology (including reticulocytes).
Measurement of aerobic capacity (endurance)
时间窗: 7 days before training and 7-10 days after the training. Training will last 4 weeks.
Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)
Measurement of anaerobic capacity
时间窗: 7 days before training and 7-10 days after the training. Training will last 4 weeks
Measurement of maximal anaerobic power (Wingate Anaerobic Test)
Somatic indices
时间窗: 7 days before training and 7-10 days after the training. Training will last 4 weeks.
Body composition analysis ( body height \[m\], body mass \[kg\], Quetelet II Index \[kg/m\^2\], lean body mass \[kg\], fat mass \[kg\], fat percentage \[%\] and total water content \[kg\]
次要结局
未报告次要终点