Serum Pepsinogen After Helicobacter Pylori Eradication for the Gastric Cancer Prevention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Serum pepsinogen change after H. pylori eradication
研究概览
简要总结
Helicobacter pylori has been recognized as a major pathogen in gastric carcinogenesis. Current guidelines recommend the H. pylori "test-and-treat" strategy for the purpose of primary and secondary gastric cancer prevention. Considering the "point of no return" theory, however, H. pylori eradication cannot reduce the risk of gastric cancer in subjects with gastric atrophy and intestinal metaplasia. The intragastric hypoacidic environment is associated with the risk of intestinal-type gastric cancer development. Recently, the secretory ability of the stomach can be measured using the serum pepsinogen (PG) assay.
详细描述
This study aimed to evaluate the change of serum PGs after H. pylori eradication success and identify the optimal timing of eradication.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gastroscopy can be performed
- •Serologic markers including serum pepsinogen can be measured
排除标准
- •Age < 20 or > 70 years
- •Anemia (serum hemoglobin level < 10 g/dL)
- •Severe systemic disease
- •Advanced chronic liver disease
- •Use of certain medications, including proton pump inhibitors, H2- receptor antagonists, or antibiotics
- •History of H. pylori eradication
- •History of gastric surgery
- •Recent history of upper gastrointestinal bleeding
结局指标
主要结局
Serum pepsinogen change after H. pylori eradication
时间窗: after 8 weeks
Serum pepsinogen recovery
次要结局
未报告次要终点
研究者
Jun-Hyung Cho
Associate Professor
Soonchunhyang University Hospital