Lung Function and Exercise Response Measured by Optoelectronic Plethysmography in School-aged Children Born Preterm
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in end-expiratory lung volume with exercise
研究概览
简要总结
This study will explore lung function and respiratory health in school-aged children who were born prematurely at <32 weeks gestation. It will involve full lung function assessment, a questionnaire and discussion about respiratory health, and an exercise test using optoelectronic plethysmography (OEP) to measure breathing patterns.
详细描述
Preterm are born during a critical stage of lung development, and can have abnormalities in lung function that persist with age. Previous studies have shown that children with BPD have reduced lung function and limited exercise capacity. These studies have used conventional lung function testing which requires a tight fitting mask. This is uncomfortable, may alter normal breathing patterns and cannot measure changes in total lung volume.
Optoelectronic plethysmography (OEP) indirectly measures lung volumes and breathing patterns using cameras to track the position of marker stickers on the chest, back and abdomen. It is comfortable, does not require a mask and allows us to track changes in total lung volume.
This study will use standard lung function testing and OEP to measure lung function and breathing patterns at rest and during exercise in school-aged children born prematurely, compared to healthy children born at full term. All participants will complete standard lung function tests, a questionnaire and structured interview to qualitatively assess respiratory health, and an exercise test using OEP to assess how breathing changes with exercise.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 8 Years 至 16 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 8-16 years
- •Born at <32 weeks gestation (preterm) or >37 weeks gestation (controls)
- •Parental consent obtained
排除标准
- •Unable to comply with test procedure
- •Respiratory illness within last 2 weeks
- •Cardiac disease (excludes ligated PDA)
- •Neuromuscular disease
结局指标
主要结局
Change in end-expiratory lung volume with exercise
时间窗: Pre + post exercise (10minutes)
Change in end-expiratory lung volume measured in litres with exercise measured using optoelectronic plethysmography
次要结局
- Forced vital capacity (FVC)(Baseline)
- Forced mid-expiratory flow (FEF25-75%)(Baseline)
- Change in tidal volume with exercise(During exercise (10 minutes))
- Change in minute ventilation with exercise(During exercise (10 minutes))
- Baseline forced expiratory volume in 1 second (FEV1)(Baseline)
- Transfer factor for carbon monoxide (TLCO)(Baseline)
- Body plethysmography(Baseline)
- FeNO(Baseline)
- Exercise induced bronchoconstriction(10 minutes post exercise)
- Baseline activity levels(1 week period)
