跳至主要内容
临床试验/NCT03330054
NCT03330054Unknown不适用

Frequency Of Eye Problems In Type 2 Diabetes With Chronic Kidney Disease

Mohammed Ramadan Abdallah0 个研究点目标入组 100 人开始时间: 2017年12月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
100
主要终点
Frequency Of Eye problems In Type 2 Diabetes with Chronic Kidney Disease

研究概览

简要总结

This study evaluate the frequency and type of eye problem among Type 2 Diabetics with renal impairment and effect of renal impairment and haemodialysis on diabetic retinopathy

详细描述

Chronic kidney disease is a descriptive term and is used for deteriorating kidney function of any underlying cause. Chronic kidney disease implies longstanding (>3 months), potentially progressive, impairment in renal function.(Kumar & Clark's ., 2016).

Diabetes mellitus is the most common cause of chronic kidney disease in developed countries. In patients with diabetes, there is a steady advance from microalbuminuria to dipstick positive proteinuria and a progression to renal failure. (Davidson's.,2014) .The most commonly diagnosed diabetes-related complications is diabetic retinopathy. Its prevalence increases with the duration of diabetes. Some 20%of people with type 1 diabetes will have retinal changes after 10 years, rising to >95% after20 years; 20-30% of people with type 2 diabetes have retinopathy at diagnosis.(Kumar & Clark's ., 2016) .

Also from risk factors of diabetic retinopathy is nephropathy, and if severe, is associated with worsening of Diabetic retinopathy. Conversely, treatment of renal disease (e.g. renal transplantation) may be associated with improvement of retinopathy and a better response to photocoagulation.(Kanaski ,2016) The high burden of ocular disease in Chronic kidney disease can be explained, in part, by the sharing of risk factors common to both kidney and eye diseases such as age, smoking, hypertension, diabetes, raised serum cholesterol and obesity. Ocular diseases may also be directly linked to chronic kidney disease via common pathogenic pathways, including, atherosclerosis, microangiopathy, inflammation and oxidative stress (Wong et al., 2014).

In our study we seek to do the following for participants :

  1. A detailed history including

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • 50 patients Type 2 Diabetes without renal impairment.
  • 25 patients Type 2 Diabetes with chronic kidney disease not on replacement therapy. (stage I-IV)
  • 25 patients Type 2 Diabetes with end-stage renal disease on haemodialysis

排除标准

  • patients with previous history of eye problems and any systemic disease.
  • Type 1 Diabetics .
  • Acute kidney injury in Diabetics.

结局指标

主要结局

Frequency Of Eye problems In Type 2 Diabetes with Chronic Kidney Disease

时间窗: 2 days for each participant to be assessed

To evaluate the frequency and type of eye problem among: 1. Type 2 Diabetics not having renal impairment. 2. Type 2 Diabetics with chronic kidney disease not on replacement therapy. 3. Type 2 Diabetics with end stage renal disease on haemodialysis.

次要结局

未报告次要终点

研究者

发起方
Mohammed Ramadan Abdallah
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Mohammed Ramadan Abdallah

Principal Investigator

Assiut University

相似试验