Prevalence of Cusp Asymmetry , Coronary Ostial Eccentricity in Patients Undergoing Trans Catheter Aortic Valve Implantation and Their Impact on Coronary Ostial OverlaP Risk Assessment: an Egyptian CO-OPRA Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Coronary Ostia Overlap with neo-commissures
研究概览
简要总结
The goal of this observational study is to measure the prevalence of Cusps asymmetry, coronary Ostial eccentricity in patients with severe aortic stenosis undergoing Trans-catheter Aortic Valve Implantation (TAVI) and measure the degree of coronary ostia overlap with trans-catheter neo-commissure. The main question it aims to answer is:
Do coronary ostial eccentricity or cusp asymmetry have impact on coronary ostia overlap with trans-catheter neo-commissure? Participants already taking TAVI as part of their regular medical care for severe symptomatic aortic stenosis will do post procedural ECG-gated non contrast Multi-detector Computed Tomographic Angiography (MDCTA).
详细描述
All patients will be subjected to:
Pre-procedural data:
- Proper history taking including:
- Age.
- Sex
- Body weight, height, and calculated body mass index
- Previous related medical history (Hypertensive, Diabetic, Rheumatic heart disease, Peripheral vascular disease, Cerebrovascular disease, Chronic kidney disease, Chronic lung disease.)
- Previous coronary artery disease (completely revascularized or non-revascularized)
- Previous related surgical history (Surgical valve replacement, Coronary artery bypass graft surgery (CABG) or PCI, Peripheral vascular stenting or bypass graft surgery and carotid stenting or endarterectomy).
- 12-lead surface electrocardiogram (ECG):
- Intrinsic rhythm.
- PR interval duration.
- QRS duration.
- Presence or absence of bundle branch block.
- Baseline ischemic ECG changes (Q waves, ST segment depression or elevation and T wave inverted or flat).
- Transthoracic echocardiography:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe Aortic stenosis with tri-leaflets aortic valve undergoing Trans catheter Aortic valve Implantation
排除标准
- •severe Aortic stenosis with bicuspid leaflets aortic valve
- •severe Aortic stenosis undergoing surgical aortic valve replacement
结局指标
主要结局
Coronary Ostia Overlap with neo-commissures
时间窗: With in 30 days from indexed procedure
Measuring angle between trans catheter Aortic valve neo-commissures and coronary Ostia
次要结局
未报告次要终点