Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Change in adherence to Health Passport recommendations-Physical/Cardiovascular Health (HPAI-PC)
研究概览
简要总结
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA). The study is designed to help older adults in the Washington, D.C., Maryland, and Virginia (DMV) area maintain independence, mobility, wellbeing and brain health as they age.
Adults aged 50 years and older will receive a comprehensive health assessment at the study site, Center for Optimal Aging- ALOHA Lab at Marymount University (MU) Ballston Campus in Arlington, Virginia. The assessment includes physical and cognitive testing, health and medical history, lifestyle surveys, and biometric measures such as blood pressure, grip strength, body composition by the InBody system, balance and gait speed. Participants will receive their results in a personalized "Health Passport," which summarizes findings and provides tailored recommendations to help manage modifiable health risk factors-such as those linked to Alzheimer's disease, cardiovascular disease, frailty syndrome, and depression.
Participants will return annually for up to 5 years to repeat assessments and receive updated health and wellness recommendations. The study will track changes in health over time and explore the impact of the Health Passport on health behaviors, functional independence, and quality of life. ALOHA will also evaluate the cultural appropriateness of the Health Passport for diverse populations in Northern Virginia.
The program incorporates an interprofessional research model, engaging researchers from multiple health professions to work alongside older adults, supporting both participants' wellness and optimal aging.
详细描述
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is an interdisciplinary, mixed-method, longitudinal research program aimed at identifying, tracking, and managing modifiable health risk factors that influence optimal aging. The study serves community-dwelling adults aged 50 and older living in the DMV region, with initial recruitment focused on healthy individuals without significant cognitive impairment or terminal illness.
The ALOHA framework combines comprehensive baseline and follow-up health assessments with personalized wellness guidance. At enrollment, participants undergo:
- Physical health evaluations (vital signs, body composition via bioimpedance, cardiovascular function via arteriography, mobility and endurance tests, grip strength, flexibility, balance)
- Cognitive assessments (Montreal Cognitive Assessment, Central Nervous System [CNS] Vital Signs, Wechsler Memory and Intelligence scales, Quality of Life in Neurological Disorders [Neuro-QOL] Cognitive Function survey)
- Lifestyle and psychosocial surveys (physical activity, diet quality using the MIND diet score, depression screening via the Center for Epidemiologic Studies Depression Scale [CES-D], social determinants of health, oral health, self-efficacy, quality of life)
Findings are compiled into a tailored, participant-specific, "Health Passport," which summarizes results in accessible language and offers practical, evidence-based recommendations for reducing disease risk, improving physical and cognitive function, and promoting overall wellness.
Participants return annually for up to five years to repeat assessments, receive an updated Health Passport consultation, and complete follow-up surveys regarding adherence, satisfaction, and changes in health status. The longitudinal design allows researchers to examine health trajectories, the effectiveness of early prevention strategies, and the relationship between modifiable risk factors and outcomes such as functional independence and cognitive decline.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50 years or older at time of enrollment
- •Residing in the Washington, District of Columbia (DC)., Maryland, or Virginia metropolitan areas
- •Community-dwelling (living independently or with minimal assistance)
- •Able to participate in physical and cognitive assessments
- •Able to provide informed consent
- •Willing to return for annual follow-up assessments for up to 5 years
排除标准
- •Diagnosis of dementia or significant cognitive impairment that prevents informed consent or participation in assessments
- •Severe physical disability or medical condition that precludes participation in study assessments (e.g., unstable cardiac condition, severe mobility limitation)
- •Current diagnosis of a terminal illness with life expectancy less than 12 months
- •Residing in a long-term care facility or nursing home at time of enrollment
- •Inability to communicate in English or Spanish (study materials available in these languages only)
- •Participation in another interventional trial that could confound study results
研究组 & 干预措施
ALOHA Health Passport Cohort
Community-dwelling adults aged 50 and older who receive a comprehensive baseline and annual health assessment at the Marymount University Center for Optimal Aging. Assessments include physical, cognitive, and psychosocial measures. Results are compiled into a personalized "Health Passport" with tailored recommendations for managing modifiable health risk factors. Participants return annually for up to 5 years to monitor health changes, update recommendations, and complete follow-up surveys on adherence and outcomes.
结局指标
主要结局
Change in adherence to Health Passport recommendations-Physical/Cardiovascular Health (HPAI-PC)
时间窗: Baseline and 12 months (with annual re-testing up to 5 years, per protocol).
Health Passport Adherence Index (HPAI) Physical/Cardiovascular health; study-specific index. 5-item Likert index (0-4 per item), domain total 0-20; higher = better adherence. Unit: points.
Change in adherence to Health Passport recommendations-Cognitive, Sleep, and Mental Health (HPAI-CSM)
时间窗: Baseline and 12 months (with annual re-testing up to 5 years, per protocol).
Health Passport Adherence Index (HPAI) for Cognitive, Sleep and Mental Health. 5-item Likert index (0-4 per item), domain total 0-20; higher = better adherence. Unit: points.
次要结局
- Change in falls incidence (self-report)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in Montreal Cognitive Assessment (MoCA) score(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in static balance (Four-Stage Balance Test)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in adherence to Health Passport recommendations-Diet and Oral Health (HPAI-DO)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in adherence to Health Passport recommendations-Social Health (HPAI-SH)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in walking endurance (200-Meter Fast Walk Test)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Pain Interference(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Anxiety(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Satisfaction with Social Roles(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Physical Function(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in depressive symptoms (CES-D-20)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in self-reported cognitive function (Neuro-QOL v2.0 Cognitive Function)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in gait speed (10-Meter Walk Test)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Sleep Disturbance(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Fatigue(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in PROMIS-57 Depression(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in Central Nervous System (CNS) Vital Signs composite scores(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in systolic and diastolic blood pressure(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in body composition (bioimpedance)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in MIND Diet Score(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in Timed Up and Go (TUG) test scores(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in 6-Minute Walk Test distance(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in Body Mass Index (BMI)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in oral-health-related quality of life (GOHAI)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
- Change in perceived stress (A-SDH)(Baseline and 12 months (with annual re-testing up to 5 years, per protocol).)
研究者
Patricia C. Heyn
Vice President for Research
Marymount University