NCT01943812已完成4 期
Substituted Frozen Embryo Transfer Cycles With GnRH-agonist Supplementation
Peter Humaidan2 个研究点 分布在 1 个国家目标入组 287 人开始时间: 2013年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 287
- 试验地点
- 2
- 主要终点
- Pregnancy loss rate
研究概览
简要总结
The aim of this study is to compare two FET protocols by modifying the substituted FET cycle in order to maintain a higher ongoing positive pregnancy rate and thus reduce the early pregnancy loss.
Hypothesis: adding GnRH-agonist to the substituted cycle in FET treatment reduces the early pregnancy loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Endometrial thickness ≥ 7 mm after stimulation
- •18-45 years
- •IVF/ICSI fertilisation
- •BMI > 18,5 <30 kg/m2
- •cycle length 25-34 days
排除标准
- •endometrial thickness < 7 mm or no triple layer endometrium and/or functional follicles
- •Uterine abnormality
- •Chronic medical disease
- •oocyte donation cycles
研究组 & 干预措施
Substituted FET cycle and GnRHa
Experimental
Substituted FET GnRH-a 2 bolus two days before Estradiol 6 mg Progesterone (Crinone) 180 mg
干预措施: Estradiol and progeterone (Drug)
Substituted FET cycle
Active Comparator
substituted FET cycle Estradiol Progesterone
干预措施: Estradiol and progeterone (Drug)
结局指标
主要结局
Pregnancy loss rate
时间窗: Primary outcome is avaible after 12th week of gestational.
次要结局
- Pregnancy rate(14 days after embryo transfer.)
研究者
Peter Humaidan
D.M.Sc., M.D.
Regionshospitalet Viborg, Skive
研究点 (2)
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