Troponin Excretion in Urine in Patients With and Without Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- Troponin I in blood vs. urine
研究概览
简要总结
In this study, in order to better understand the mechanism of troponin clearance and the reason for elevated troponin levels in patients with CKD, we aim to evaluate quantitatively the excretion of troponin in the urine in patients with and without CKD, and with and without myocardial injury. We will compare urinary troponin levels with blood troponin levels in these patients. In addition, we will compare the levels of hs-cTnT and hs-cTnI in the patients' sera and urine.
详细描述
The study population will be screened at the internal wards, the nephrology ward and clinic, and the intensive cardiac care unit (ICCU) of Soroka Medical Center. It will include patients who suffer from AMI, patients with CKD with and without any cardiac disease and patients with no known renal or cardiac disease.
The following information and measurements will be collected:
Demographics - age, sex, weight, height. Past medical history - specifically regarding renal and cardiac diseases and procedures.
Measured variables in blood serum - troponin T, troponin I, creatinine, total protein, albumin, myoglobin Measured variables in urine - troponin T, troponin I, creatinine, total protein, albumin, microalbumin, β2-microglobulin Calculations - GFR (according to MDRD equation), troponin correction to creatinine (gr troponin per gr creatinine), troponin excretion ( ), urine albumin/creatinine ratio, urine protein/creatinine ratio.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who are able to give informed consent.
排除标准
- •Pregnant women
- •Patients after kidney transplantation.
- •Patients after heart transplantation.
- •Anuric patients.
结局指标
主要结局
Troponin I in blood vs. urine
时间窗: 1 year
Quantitative measurements of hs-cTnI in blood and urine
Troponin T in blood vs. urine
时间窗: 1 year
Quantitative measurements of hs-cTnT in blood and urine
次要结局
- Troponin excretion in urine compared to albumin(1 year)
- Troponin excretion in urine compared to creatinine(1 year)
- Troponin excretion in urine compared to β2-microglobulin(1 year)
研究者
Yasmeen Abu Fraiha
Internal Medicine Resident, Internal Medicine Department B
Soroka University Medical Center