High Sensitivity Troponin T Levels Following Elective External Direct Current Cardioversion for Atrial Fibrillation / Atrial Flutter
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- High Sensitivity Troponin T levels pre and 6 hours post cardioversion
研究概览
简要总结
The purpose of this study is to determine if there is a rise in serum high sensitivity troponin T (a marker for heart muscle injury) following a direct current cardioversion (shock therapy) used for patients with atrial fibrillation. This will help us determine if direct current cardioversion results in damage to the heart muscles in a sufficient amount to cause a rise in high sensitivity troponin T.
详细描述
High sensitivity Troponin T is a relatively new biomarker that is highly sensitive and specific for myocardial injury. Its widespread use has helped in the determination and investigation for myocardial ischemia in patients. Previous studies have shown a rise in creatine kinase (CK) and the more specific creatine kinase-MB isoenzyme (CKMB) after DC cardioversion. Studies on the earlier generation troponin T found that the levels don't rise or rise only minimally after DC cardioversion. The high sensitivity troponin T has never been studied in the setting of DC cardioversion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with atrial fibrillation / atrial flutter attending for direct current external cardioversion
- •Age 18 or older
排除标准
- •Myocardial infarction within the last 6 weeks
- •Coronary artery bypass grafting, percutaneous coronary intervention or any other invasive cardiac procedure within the last 6 weeks
结局指标
主要结局
High Sensitivity Troponin T levels pre and 6 hours post cardioversion
时间窗: 1 year
次要结局
- Creatine Kinase levels pre and 6 hours post cardioversion(1 year)
- B-type Natriuretic Peptide (BNP) levels pre and 6 hours post cardioversion(1 year)
- Neutrophil Gelatinase-associated Lipocalin (NGAL) levels pre and 6 hours post cardioversion(1 year)
研究者
Ronstan Lobo, MB, BMedSc, MRCPI, MRCP(UK)
Dr.
University of Limerick